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Integrin beta 3 antibody (ITGB3) (pTyr785)

Details for Product anti-ITGB3 Antibody No. ABIN658968, Supplier: Log in to see
Antigen
  • CD61
  • GP3A
  • INGRB3
  • BDPLT16
  • BDPLT2
  • GPIIIa
  • GT
  • INTB3
  • integrin
  • GPIIIA
Epitope
pTyr785
39
38
28
17
13
9
6
5
5
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
413
169
112
19
19
14
13
10
8
7
5
5
5
4
3
3
3
2
2
1
1
Host
Mouse
235
203
61
7
2
1
Clonality
Monoclonal
Conjugate
This Integrin beta 3 antibody is un-conjugated
75
48
20
10
9
5
4
4
3
2
2
2
2
2
2
2
Application
Western Blotting (WB)
262
226
107
68
67
58
56
24
23
11
11
11
6
5
5
5
4
4
2
2
2
2
Supplier
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Isotype IgG
Specificity The antibody was affinity-purified from rabbit antiserum using epitope-specific phosphopeptide column, and the antibody against non-phosphopeptide was removed using non-phosphopeptide column corresponding to the phosphorylation site.
Purification Affinity purified
Alternative Name Integrin Beta-3 (ITGB3 Antibody Abstract)
Background The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
Synonyms: CD_antigen=CD61, Flags: Precursor, Platelet membrane glycoprotein IIIa, GPIIIa, Integrin beta-3
Molecular Weight 87058 DA
Gene ID 3690
UniProt P05106
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
Pathways
Application Notes The suggested dilution is: WB: 1:500-1:1000
Comment

Background: The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

Restrictions For Research Use only
Format Liquid
Concentration 1mg/ml
Buffer PBS, 0.02% sodium azide and 50% glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Addad, Elalamy, Chakroun et al.: "Platelet glycoprotein IIIa (platelet antigen 1/platelet antigen 2) polymorphism and 1-year outcome in patients with stable coronary artery disease." in: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Vol. 21, Issue 7, pp. 674-8, 2010 (PubMed).

Motovska, Kvasnicka, Hajkova et al.: "Platelet gene polymorphisms and risk of bleeding in patients undergoing elective coronary angiography: a genetic substudy of the PRAGUE-8 trial." in: Atherosclerosis, Vol. 212, Issue 2, pp. 548-52, 2010 (PubMed).

Romero, Friel, Velez Edwards et al.: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).

Nie, Zhou, Fu et al.: "The allele frequencies of HPA 1-16 determined by PCR-SSP in Chinese Cantonese donors." in: Transfusion medicine (Oxford, England), Vol. 20, Issue 6, pp. 376-82, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).