|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Aldehyde Dehydrogenase 5 Family, Member A1 (ALDH5A1) antibody
|Synonyms||SSDH, SSADH, Ssadh, ALDH5A1, Ahd1, Ahd-1, Ssdh1, Aldh5a1, 6330403E24Rik, D630032B01Rik, OTTMUSG00000000613|
Alternatives Western Blotting (WB), ELISA
|5 references available|
|Quantity||0.1 mg (0.25 mg/ml) (Variants)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This ALDH5A1 antibody is generated from mouse immunized with ALDH5A1 recombinant protein.|
|Description||Other names: Aldehyde dehydrogenase family 5 member A1, NAD(+)-dependent succinic semialdehyde dehydrogenase, Succinate-semialdehyde dehydrogenase, mitochondrial,SSADH, ALDH5A1|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||This ALDH5A1 antibody is generated from mouse immunized with ALDH5A1 recombinant protein.|
|Molecular Weight||57215 DA|
Background: This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene.
|Application Notes||The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100|
|Buffer||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cell Structure|
|Restrictions||For Research Use only|
Saito, Kawamoto, Kamatani: "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects." in: Journal of human genetics, Vol. 54, Issue 6, pp. 317-23, 2009 (PubMed).
Pearl, Gibson, Quezado et al.: "Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency." in: Neurology, Vol. 73, Issue 6, pp. 423-9, 2009 (PubMed).
Joslyn, Ravindranathan, Brush et al.: "Human variation in alcohol response is influenced by variation in neuronal signaling genes." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 5, pp. 800-12, 2010 (PubMed).
Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).
Jia, Wang, Meltzer et al.: "Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data." in: Schizophrenia research, Vol. 122, Issue 1-3, pp. 38-42, 2010 (PubMed).
|Hosts||Rabbit (20), Goat (6), Mouse (1)|
|Reactivities||Human (27), Mouse (Murine) (11), Rat (Rattus) (11), Cow (Bovine) (3), Dog (Canine) (3), Cat (Feline) (1), Chicken (1)|
|Applications||Western Blotting (WB) (26), ELISA (20), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6), Immunohistochemistry (IHC) (4), Flow Cytometry (FACS) (1), Immunofluorescence (IF) (1), Immunoprecipitation (IP) (1)|
|Epitopes||C-Term (4), AA 301-312 (2), AA 485-496 (2), N-Term (2), Internal Region (1)|