Aldehyde Dehydrogenase 5 Family, Member A1 (ALDH5A1) antibody

Antigen: Aldehyde Dehydrogenase 5 Family, Member A1 (ALDH5A1)

Synonyms: SSDH, SSADH, Ssadh, ALDH5A1, Ahd1, Ahd-1, Ssdh1, Aldh5a1, 6330403E24Rik, D630032B01Rik, OTTMUSG00000000613

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN659008

Additional Information

Alternative name: ALDH5A1

Gene ID: 7915

UniProt: P51649

Immunogen: This ALDH5A1 antibody is generated from mouse immunized with ALDH5A1 recombinant protein.

Isotype: IgG1, IgK

Description: Other names: Aldehyde dehydrogenase family 5 member A1, NAD(+)-dependent succinic semialdehyde dehydrogenase, Succinate-semialdehyde dehydrogenase, mitochondrial,SSADH, ALDH5A1

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: This ALDH5A1 antibody is generated from mouse immunized with ALDH5A1 recombinant protein.

Molecular Weight: 57215 DA

Comments:

Background: This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500 Immunohistochemistry ~~ 1:50~100

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure

Restrictions: For Research Use only

Publications

Product: Saito, Kawamoto, Kamatani: "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects." in: Journal of human genetics, Vol. 54, Issue 6, pp. 317-23, 2009 (PubMed).

Pearl, Gibson, Quezado et al.: "Decreased GABA-A binding on FMZ-PET in succinic semialdehyde dehydrogenase deficiency." in: Neurology, Vol. 73, Issue 6, pp. 423-9, 2009 (PubMed).

Joslyn, Ravindranathan, Brush et al.: "Human variation in alcohol response is influenced by variation in neuronal signaling genes." in: Alcoholism, clinical and experimental research, Vol. 34, Issue 5, pp. 800-12, 2010 (PubMed).

Rose, Behm, Drgon et al.: "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score." in: Molecular medicine (Cambridge, Mass.), Vol. 16, Issue 7-8, pp. 247-53, 2010 (PubMed).

Jia, Wang, Meltzer et al.: "Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data." in: Schizophrenia research, Vol. 122, Issue 1-3, pp. 38-42, 2010 (PubMed).