BMP2B antibody, BMP2B1 antibody, MCOPS6 antibody, OFC11 antibody, ZYME antibody, Bmp-4 antibody, Bmp2b antibody, Bmp2b-1 antibody, Bmp2b1 antibody, BOMPR4A antibody, bmp-4 antibody, zbmp-4 antibody, zgc:100779 antibody, BMP-4 antibody, XBMP-4 antibody, bmp2b antibody, bmp2b1 antibody, bmp4 antibody, ofc11 antibody, xbmp4 antibody, zyme antibody, BMP4 antibody, bone morphogenetic protein 4 antibody, bone morphogenetic protein 4 L homeolog antibody, bone morphogenetic protein 4 S homeolog antibody, BMP4 antibody, Bmp4 antibody, bmp4 antibody, bmp4.L antibody, bmp4.S antibody
Background
The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.