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Unc-51 Like Kinase 2 (C. Elegans) (ULK2) antibody

Details for Product No. ABIN659089
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Antigen
Synonyms ULK2, ATG1B, Unc51.2, A830085I22Rik, AU015340, mKIAA0623
Reactivity
Human
(55), (4), (1)
Host
Mouse
(37), (19)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB)
(41), (33), (12), (9), (5), (4), (2)
Pubmed 4 references available
Quantity 0.1 mL
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Catalog No. ABIN659089
291.50 $
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Immunogen This ULK2 monoclonal antibody is generated from mouse immunized with ULK2 recombinant protein.
Clone 218CT21-2-6
Isotype IgM, kappa
Specificity This ULK2 monoclonal antibody is generated from mouse immunized with ULK2 recombinant protein.
Purification Ascites
Alternative Name ULK2
Background This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq].
Synonyms: ULK2,Serine/threonine-protein kinase ULK2,KIAA0623
Molecular Weight 112694 DA
Gene ID 9706
UniProt Q8IYT8
Research Area Cell Structure, Signaling, Protein Modifications, Cell Signaling, Chromatin, Phospho-specific antibodies
Application Notes WB = 1:100-3200
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Unc-51 Like Kinase 2 (C. Elegans) (ULK2) antibody ULK2 antibody western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the ULK2 antibody detected the ULK2 protein (arrow).
Background publications Yan, Kuroyanagi, Tomemori et al.: "Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains." in: Oncogene, Vol. 18, Issue 43, pp. 5850-9, 1999 (PubMed).

Tomoda, Kim, Zhan et al.: "Role of Unc51.1 and its binding partners in CNS axon outgrowth." in: Genes & development, Vol. 18, Issue 5, pp. 541-58, 2004 (PubMed).

Stelzl, Worm, Lalowski et al.: "A human protein-protein interaction network: a resource for annotating the proteome...." in: Cell, Vol. 122, Issue 6, pp. 957-68, 2005 (PubMed).

Watkins, Rukazenkov: "Response to 'Clinical outcomes in NSCLC patients with EGFR mutations: pooled analysis'
(Paz-Ares et al., J Cell Mol Med. 2010; 14: 51-69)." in: Journal of cellular and molecular medicine, Vol. 14, Issue 11, pp. 2693-4, 2010 (PubMed).

Validation Images
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