Unc-51 Like Kinase 2 (C. Elegans) (ULK2) antibody

Antigen: Unc-51 Like Kinase 2 (C. Elegans) (ULK2)

Synonyms: ULK2, MGC160050, Unc51.2, AU015340, mKIAA0623, A830085I22Rik

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN659090

Additional Information

Alternative name: ULK2

Gene ID: 9706

UniProt: NP_055498.3, NP_001136082.1, Q8IYT8

Immunogen: This ULK2 monoclonal antibody is generated from mouse immunized with ULK2 recombinant protein.

Isotype: IgM, kappa chain

Description: Other names: 218CT21.2.6

Characteristics: Synthetic peptide

Specificity: This ULK2 monoclonal antibody is generated from mouse immunized with ULK2 recombinant protein.

Molecular Weight: 112694 DA

Comments:

Background: This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq].

Application Details

Application Notes: The suggested dilution is: ELISA~~1:1000 Western blotting~~ 1:20~100

Concentration: 0.25 mg/ml

Buffer: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Structure, Signaling, Protein Modifications, Cell Signaling, Chromatin, Phospho-specific antibodies

Restrictions: For Research Use only

Publications

Product: Yan, Kuroyanagi, Tomemori et al.: "Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains." in: Oncogene, Vol. 18, Issue 43, pp. 5850-9, 1999 (PubMed).

Tomoda, Kim, Zhan et al.: "Role of Unc51.1 and its binding partners in CNS axon outgrowth." in: Genes & development, Vol. 18, Issue 5, pp. 541-58, 2004 (PubMed).

Stelzl, Worm, Lalowski et al.: "A human protein-protein interaction network: a resource for annotating the proteome." in: Cell, Vol. 122, Issue 6, pp. 957-68, 2005 (PubMed).

Watkins, Rukazenkov: "Response to 'Clinical outcomes in NSCLC patients with EGFR mutations: pooled analysis'
(Paz-Ares et al., J Cell Mol Med. 2010; 14: 51-69)." in: Journal of cellular and molecular medicine, Vol. 14, Issue 11, pp. 2693-4, 2010 (PubMed).