Transforming Growth Factor, beta 2 (TGFB2) antibody

Details for Product No. ABIN659105
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Antigen
Synonyms LDS4, TGF-beta2, tgf-beta2, tgfb2-A, TGFbeta2, MGF, Tgfb-2, BB105277, Tgf-beta2, TGF-B2, TGFB2
Reactivity
Human
(89), (48), (47), (15), (14), (14), (12), (4), (2), (1), (1), (1), (1), (1)
Host
Mouse
(97), (11), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application
Western Blotting (WB)
(65), (50), (36), (26), (20), (17), (13), (5), (3), (3), (2), (1), (1)
Pubmed 2 references available
Catalog no. ABIN659105
Quantity 0.1 mL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This TGFB2 monoclonal antibody is generated from mouse immunized with TGFB2 recombinant protein.
Clone 220ct16-4-3-1
Isotype IgG1, kappa
Specificity This TGFB2 monoclonal antibody is generated from mouse immunized with TGFB2 recombinant protein.
Purification Ascites
Alternative Name TGFB2
Background This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1,7)(q41,p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms: 220ct16.4.3.1
Molecular Weight 47748 DA
Gene ID 7042
UniProt P61812, NP_001129071.1, NP_003229.1
Research Area Cell Structure, Signaling, Protein Modifications, Cell Cycle, Cell Signaling, Chromatin
Application Notes WB = 1:500-16000
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Transforming Growth Factor, beta 2 (TGFB2) antibody TGFB2 antibody western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TGFB2 antibody detected the TGFB2 protein (arrow).
Background publications Sambo, Trovoada, Benchimol et al.: "Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children." in: PLoS ONE, Vol. 5, Issue 6, pp. e11141, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Hosts (97), (11), (1), (1)
Reactivities (89), (48), (47), (15), (14), (14), (12), (4), (2), (1), (1), (1), (1), (1)
Applications (65), (50), (36), (26), (20), (17), (13), (5), (3), (3), (2), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Epitopes (10), (4), (4), (2), (1), (1), (1), (1), (1)
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