Autophagy Related 4D, Cysteine Peptidase (ATG4D) antibody

Details for Product No. ABIN659111
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Antigen
Reactivity
Human
(84), (60), (40), (38), (38), (36)
Host
Mouse
(82), (10), (3), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(6), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (2)
Application
Western Blotting (WB)
(56), (40), (26), (19), (15), (6), (5), (3)
Pubmed 3 references available
Quantity 0.1 mL
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Catalog No. ABIN659111
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Immunogen This ATG4D monoclonal antibody is generated from mouse immunized with ATG4D recombinant protein.
Clone 222CT15-4-1
Isotype IgG1, kappa
Specificity This ATG4D monoclonal antibody is generated from mouse immunized with ATG4D recombinant protein.
Purification Ascites
Alternative Name ATG4D
Background Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases.
Synonyms: 222CT15.4.1
Molecular Weight 52922 DA
Gene ID 84971
NCBI Accession NP_116274
UniProt Q86TL0
Research Area Autophagy, Cell Structure, Metabolism
Application Notes WB = 1:500-16000
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Autophagy Related 4D, Cysteine Peptidase (ATG4D) antibody ATG4D antibody western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ATG4D antibody detected the ATG4D protein (arrow).
Background publications Mariño, Uría, Puente et al.: "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy." in: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 3671-8, 2003 (PubMed).

Lamesch, Li, Milstein et al.: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007 (PubMed).

Betin, Lane: "Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis." in: Journal of cell science, Vol. 122, Issue Pt 14, pp. 2554-66, 2009 (PubMed).

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