Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 (MAP4K3) antibody

Details for Product No. ABIN659122
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Antigen
Synonyms GLK, MAPKKKK3, MEKKK 3, MEKKK3, RAB8IPL1, 4833416M01Rik, 4833416M07Rik, 9530052P13Rik, Glk
Reactivity
Human
(26), (12), (12)
Host
Mouse
(22), (4)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB)
(24), (11), (4), (4), (2), (2)
Pubmed 1 reference available
Catalog no. ABIN659122
Quantity 0.1 mL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This MAP4K3 monoclonal antibody is generated from mouse immunized with MAP4K3 recombinant protein.
Clone 219CT8-3-1
Isotype IgM, kappa
Specificity This MAP4K3 monoclonal antibody is generated from mouse immunized with MAP4K3 recombinant protein.
Purification Ascites
Alternative Name MAP4K3
Background This gene encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3).
Synonyms: Mitogen-activated protein kinase kinase kinase kinase 3,MAP4K3,RAB8IPL1
Molecular Weight 101316 DA
Gene ID 8491
UniProt NP_003609.2, Q8IVH8
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000-8000
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment MAP4K3 Antibody (ascites) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3 (MAP4K3) antibody MAP4K3 western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the MAP4K3 antibody detected the MAP4K3 protein (arrow).
Background publications Yan, Mieulet, Burgess et al.: "PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR." in: Molecular cell, Vol. 37, Issue 5, pp. 633-42, 2010 (PubMed).

Hosts (22), (4)
Reactivities (26), (12), (12)
Applications (24), (11), (4), (4), (2), (2)
Epitopes (2), (2), (1), (1)
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