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MAP4K3 antibody (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3)

Details for Product anti-MAP4K3 Antibody No. ABIN659122, Supplier: Log in to see
Antigen
  • GLK
  • MAPKKKK3
  • MEKKK 3
  • MEKKK3
  • RAB8IPL1
  • 4833416M01Rik
  • 4833416M07Rik
  • 9530052P13Rik
  • Glk
Alternatives
anti-Human MAP4K3 antibody for Western Blotting
Reactivity
Human
69
22
12
Host
Mouse
64
11
Clonality (Clone)
Monoclonal ()
Conjugate
This MAP4K3 antibody is un-conjugated
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5
5
5
5
5
Application
Western Blotting (WB)
69
46
39
33
8
2
Supplier
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Immunogen This MAP4K3 monoclonal antibody is generated from mouse immunized with MAP4K3 recombinant protein.
Clone 219CT8-3-1
Isotype IgM, kappa
Specificity This MAP4K3 monoclonal antibody is generated from mouse immunized with MAP4K3 recombinant protein.
Purification Ascites
Alternative Name MAP4K3 (MAP4K3 Antibody Abstract)
Background This gene encodes a member of the Ste20 family of serine/threonine protein kinases. The protein belongs to the subfamily that consists of members, such as germinal center kinase (GCK), that are characterized by an N-terminal catalytic domain and C-terminal regulatory domain. The kinase activity of the encoded protein can be stimulated by UV radiation and tumor necrosis factor-alpha. The protein specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway. Evidence suggests that it functions upstream of mitogen-activated protein kinase kinase kinase 1 (MEKK1). This gene previously was referred to as RAB8-interacting protein-like 1 (RAB8IPL1), but it has been renamed mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3).
Synonyms: Mitogen-activated protein kinase kinase kinase kinase 3,MAP4K3,RAB8IPL1
Molecular Weight 101316 DA
Gene ID 8491
NCBI Accession NP_003609
UniProt Q8IVH8
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Chromatin, Signaling, Cell Structure
Pathways MAPK Signaling
Application Notes WB = 1:1000-8000
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment MAP4K3 Antibody (ascites) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-MAP4K3 antibody (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3) (ABIN659122) MAP4K3 western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrate...
Background publications Yan, Mieulet, Burgess et al.: "PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR." in: Molecular cell, Vol. 37, Issue 5, pp. 633-42, 2010 (PubMed).