Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) antibody

Details for Product No. ABIN659179, Supplier: Log in to see
Antigen
  • hif1a
  • AA959795
  • HIF1alpha
  • MOP1
  • bHLHe78
  • HIF-1A
  • HIF-1alpha
  • HIF1
  • HIF1-ALPHA
  • PASD8
  • HIF1-alpha
  • hif-1a
  • hypoxia inducible factor 1 alpha
  • hypoxia inducible factor 1, alpha subunit
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • hypoxia-inducible factor 1 alpha
  • hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
  • Protein HIF-1
  • hif-1a
  • Hif1a
  • HIF1A
  • hif-1
Alternatives
anti-Human Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) antibody for ChIP DNA-Sequencing
Reactivity
Human
611
304
251
145
91
76
66
64
58
54
44
36
28
21
20
19
19
18
17
9
3
2
2
2
1
1
1
1
1
Host
Mouse
385
278
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
52
33
33
26
25
25
18
18
15
14
12
12
6
6
6
4
4
4
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
512
226
206
182
174
169
114
91
63
16
16
13
13
13
10
7
6
5
4
3
2
2
2
1
1
Options
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Immunogen This HIF1A monoclonal antibody is generated from mouse immunized with HIF1A recombinant protein.
Clone 288CT11-7-1
Isotype IgM, kappa
Specificity This HIF1A monoclonal antibody is generated from mouse immunized with HIF1A recombinant protein.
Purification Ascites
Alternative Name HIF1A (HIF1A Antibody Abstract)
Background Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified.
Synonyms: HIF1A,Hypoxia-inducible factor 1-alpha,BHLHE78, MOP1, PASD8
Research Area Ubiquitin-related antibodies, Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Pathways Positive Regulation of Peptide Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Transition Metal Ion Homeostasis, Tube Formation, Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
Application Notes WB = 1:100-1000
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) antibody (ABIN659179) HIF1A western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates ...
Background publications Gonsalves, Kalra: "Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 6253-64, 2010 (PubMed).

Hindryckx, De Vos, Jacques, Ferdinande, Peeters, Olievier, Bogaert, Brinkman, Vandenabeele, Elewaut, Laukens: "Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 6306-16, 2010 (PubMed).

Espinosa, José Carnicer, Catasus, Canet, Dangelo, Zannoni, Prat: "Myometrial invasion and lymph node metastasis in endometrioid carcinomas: tumor-associated macrophages, microvessel density, and HIF1A have a crucial role." in: The American journal of surgical pathology, Vol. 34, Issue 11, pp. 1708-14, 2010 (PubMed).

Corzo, Condamine, Lu, Cotter, Youn, Cheng, Cho, Celis, Quiceno, Padhya, McCaffrey, McCaffrey, Gabrilovich: "HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment." in: The Journal of experimental medicine, Vol. 207, Issue 11, pp. 2439-53, 2010 (PubMed).

Shen, Zhang, Liu, Zhang: "Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia." in: FEBS letters, Vol. 584, Issue 20, pp. 4366-72, 2010 (PubMed).