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Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1) antibody

Antigen

Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1)
Synonyms
BP-1, 4EBP1, 4E-BP1, PHAS-I, MGC4316, 4e-bp1, AA959816, 153432_at, 43-BP, 4E-BP, 4EBP, BcDNA.HL08053, BcDNA:HL08053, CT8705, Dm 4E-BP, Phas1, anon-WO0172774.158, d4E-BP, d4E-BP1, d4EBP, eIF4E-BP, l(2) ... show more
Clonality Monoclonal
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN659184
Quantity 0.1 ml  (Crude ascites)  (Variants)
Price 280.50 $   Plus shipping costs $45.00
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Additional Information
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Alternative name EIF4EBP1
Gene ID 1978
UniProt NP_004086.1, Q13541
Immunogen This EIF4EBP1 monoclonal antibody is generated from mouse immunized with EIF4EBP1 recombinant protein.
Isotype IgG1
Description Other names: Eukaryotic translation initiation factor 4E-binding protein 1,EIF4EBP1,
Characteristics Mouse Monoclonal Antibody (Mab)
Specificity This EIF4EBP1 monoclonal antibody is generated from mouse immunized with EIF4EBP1 recombinant protein.
Molecular Weight 12580 DA
Comments

Background: This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq].
Synonyms BP-1, 4EBP1, 4E-BP1, PHAS-I, MGC4316, 4e-bp1, AA959816, 153432_at, 43-BP, 4E-BP, 4EBP, BcDNA.HL08053, BcDNA:HL08053, CT8705, Dm 4E-BP, Phas1, anon-WO0172774.158, d4E-BP, d4E-BP1, d4EBP, eIF4E-BP, l(2)k07736, l(2)k13517, pp20, thor, DmelCG8846, CG8846, EIF4EBP1, fc04h09, Eif4ebp1, MGC64137, wu:fc04h09

Application Details
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Application Notes The suggested dilution is: ELISA~~1:1000 Western blotting~~1:500~8000
Concentration Crude ascites
Buffer Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Storage EIF4EBP1 Antibody can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure
Restrictions For Research Use only

Publications
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Product Aoyagi, Gaspar, Shenk: "Human cytomegalovirus UL69 protein facilitates translation by associating with the mRNA cap-binding complex and excluding 4EBP1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 6, pp. 2640-5, 2010 (PubMed).

She, Halilovic, Ye et al.: "4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors." in: Cancer cell, Vol. 18, Issue 1, pp. 39-51, 2010 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1)", type "Antibodies"
Hosts Rabbit (200), Mouse (21)
Reactivities Human (204), Mouse (Murine) (106), Rat (Rattus) (106), Cow (Bovine) (39), Dog (Canine) (38), Horse (Equine) (38), Pig (Porcine) (16), Chicken (10), Rabbit (1)
Applications Western Blotting (WB) (140), ELISA (84), Immunohistochemistry (IHC) (80), Immunofluorescence (IF) (65), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (43), Immunoprecipitation (IP) (7), Flow Cytometry (FACS) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (5), Immunocytochemistry (ICC) (4), Dot Blot (Dot) (3), Immunoelectron Microscopy (IEM) (2), Gel Shift (GS) (1)
Conjugates Alexa Fluor 350 (7), Alexa Fluor 488 (7), Alexa Fluor 555 (7), Alexa Fluor 647 (7), PE,Cy5.5 (7), Biotin (6), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy7 (2)
Epitopes pThr36 (29), pThr45 (12), pSer100 (8), pSer111 (7), pSer65 (7), C-Term (6), pSer64 (6), pThr70 (5), N-Term (4), pThr46,pThr37 (4), pThr70,pSer65 (4), Internal Region (3), Thr45 (3), pThr37 (3), pThr46 (3), AA 101-118 (2), Center (2), pThr37, pThr46 (2), pThr69 (2), Ser100 (1), Ser111 (1), Thr36 (1), Thr37, Thr46 (1), Thr46 (1), Thr69 (1), pSer112 (1), pSer425 (1), pThr417 (1), pTyr376,pTyr373 (1), pTyr530 (1)