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Details for Product No. ABIN659187

HLA Class II DR alpha (HLA-DRA) (AA 48-75) antibody

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Antigen
Synonyms HLA-DRA1, MLRW, DR-alpha, HLA-DRA, Mamu-DRA1
Epitope
»Alternatives AA 48-75
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN659187
Quantity 0.1 mL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This HLA-DRA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 48-75 AA from human HLA-DRA.
Clone 302CT2-3-2
Isotype IgM
Specificity This HLA-DRA monoclonal antibody is generated from mouse immunized with HLA-DRA recombinant protein.
Purification Ascites
Alternative Name HLA-DRA
Background HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
Synonyms: HLA class II histocompatibility antigen, DR alpha chain,HLA-DRA,HLA-DRA1
Molecular Weight 28607 DA
Gene ID 3122
UniProt NP_061984.2, P01903
Research Area Ubiquitin-related antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling
Application Notes Recommend dilutions: WB : 1:500-16000
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment HLA-DRA Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Hamza, Zabetian, Tenesa et al.: "Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease." in: Nature genetics, Vol. 42, Issue 9, pp. 781-5, 2010 (PubMed).

Alternatives for antigen "HLA Class II DR alpha (HLA-DRA)", type "Antibodies"
Hosts (26), (13), (1)
Reactivities (36), (4), (3), (3)
Applications (35), (14), (12), (11), (8), (5), (5), (4), (4), (2), (1), (1)
Conjugates (4)
Epitopes (5), (5), (4), (4), (2), (1), (1)
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