HLA Class II DR alpha (HLA-DRA) (AA 48-75) antibody

Details for Product No. ABIN659187
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Antigen
Synonyms HLA-DRA1, MLRW, DR-alpha, HLA-DRA, Mamu-DRA1
Epitope
AA 48-75
(5), (5), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(41), (5), (5), (5), (1), (1), (1), (1), (1)
Host
Mouse
(35), (13), (1), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (1), (1)
Application
Western Blotting (WB)
(45), (21), (16), (15), (11), (11), (10), (5), (4), (2)
Pubmed 1 reference available
Quantity 0.1 mL
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Catalog No. ABIN659187
291.50 $
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Immunogen This HLA-DRA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 48-75 AA from human HLA-DRA.
Clone 302CT2-3-2
Isotype IgM
Specificity This HLA-DRA monoclonal antibody is generated from mouse immunized with HLA-DRA recombinant protein.
Purification Ascites
Alternative Name HLA-DRA
Background HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
Synonyms: HLA class II histocompatibility antigen, DR alpha chain,HLA-DRA,HLA-DRA1
Molecular Weight 28607 DA
Gene ID 3122
NCBI Accession NP_061984
UniProt P01903
Research Area Ubiquitin-related antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling
Application Notes WB = 1:500-16000
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment HLA-DRA Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-HLA Class II DR alpha (HLA-DRA) (AA 48-75) antibody HLA-DRA Antibody western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the HLA-DRA antibody detected the HLA-DRA protein (arrow).
Background publications Hamza, Zabetian, Tenesa et al.: "Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease." in: Nature genetics, Vol. 42, Issue 9, pp. 781-5, 2010 (PubMed).

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