Toll-Like Receptor 3 (TLR3) antibody

Antigen: Toll-Like Receptor 3 (TLR3)

Synonyms: CD283

Clonality: Monoclonal

Host: Mouse

Reactivity: Please enquire

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN659190

Additional Information

Alternative name: TLR3

Gene ID: 7098

UniProt: NP_003256.1, O15455

Immunogen: This TLR3 monoclonal antibody is generated from mouse immunized with TLR3 recombinant protein.

Isotype: IgM

Description: Other names: Toll-like receptor 3,TLR3,

Characteristics: Mouse Monoclonal Antibody (Mab)

Specificity: This TLR3 monoclonal antibody is generated from mouse immunized with TLR3 recombinant protein.

Molecular Weight: 103829 DA

Comments:

Background: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Application Details

Application Notes: The suggested dilution is: ELISA~~1:1000 Western blotting~~1:100~4000

Concentration: Crude ascites

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Storage: TLR3 Antibody can be refrigerated at 2-8°,C for up to 6 months. For long term storage, place the at -20°,C.

Research Area: Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling

Restrictions: For Research Use only

Publications

Product: Zhou, Wang, Liu et al.: "A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages." in: Immunology, Vol. 131, Issue 1, pp. 40-9, 2010 (PubMed).

Perrot, Deauvieau, Massacrier et al.: "TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 4, pp. 2080-8, 2010 (PubMed).

Paone, Galli, Gabellini et al.: "Toll-like receptor 3 regulates angiogenesis and apoptosis in prostate cancer cell lines through hypoxia-inducible factor 1 alpha." in: Neoplasia (New York, N.Y.), Vol. 12, Issue 7, pp. 539-49, 2010 (PubMed).