Toll-Like Receptor 3 (TLR3) antibody

Details for Product No. ABIN659190
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Antigen
Reactivity
Mouse (Murine)
(177), (122), (63), (45), (12), (4), (1), (1), (1)
Host
Mouse
(117), (90), (9), (3), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(25), (11), (11), (9), (9), (8), (4), (3), (3), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(135), (88), (65), (52), (32), (26), (19), (15), (14), (10), (8), (6), (5), (1), (1)
Pubmed 3 references available
Quantity 0.1 mL
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Catalog No. ABIN659190
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Immunogen This TLR3 monoclonal antibody is generated from mouse immunized with TLR3 recombinant protein.
Clone 303CT19-9-2
Isotype IgM
Specificity This TLR3 monoclonal antibody is generated from mouse immunized with TLR3 recombinant protein.
Purification Ascites
Alternative Name TLR3
Background The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
Synonyms: Toll-like receptor 3,TLR3,
Molecular Weight 103829 DA
Gene ID 7098
NCBI Accession NP_003256
UniProt O15455
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling
Application Notes WB = 1:100-4000
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment TLR3 Antibody can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Toll-Like Receptor 3 (TLR3) antibody TLR3 Antibody western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the TLR3 antibody detected the TLR3 protein (arrow).
Background publications Zhou, Wang, Liu et al.: "A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages." in: Immunology, Vol. 131, Issue 1, pp. 40-9, 2010 (PubMed).

Perrot, Deauvieau, Massacrier et al.: "TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 4, pp. 2080-8, 2010 (PubMed).

Paone, Galli, Gabellini et al.: "Toll-like receptor 3 regulates angiogenesis and apoptosis in prostate cancer cell lines through hypoxia-inducible factor 1 alpha." in: Neoplasia (New York, N.Y.), Vol. 12, Issue 7, pp. 539-49, 2010 (PubMed).

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