B-Cell CLL/lymphoma 6 (BCL6) (C-Term), (AA 676-704) antibody

Details for Product No. ABIN659194
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Antigen
Synonyms bcl5, laz3, bcl6a, znf51, zbtb27, MGC132260, Bcl5, BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
Epitope
C-Term, AA 676-704
(18), (10), (5), (5), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(59), (28), (23)
Host
Mouse
(52), (9), (1)
Clonality (Clone)
Monoclonal ()
Application
Western Blotting (WB), Immunofluorescence (IF)
(47), (23), (20), (9), (8), (7), (3), (2), (2), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
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Catalog No. ABIN659194
291.50 $
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Immunogen This BCL6 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 676-704 AA from the C-terminal region of human BCL6.
Clone 305CT16-3-3
Isotype IgG1
Specificity This BCL6 monoclonal antibody is generated from mouse immunized with BCL6 recombinant protein.
Purification Ascites
Alternative Name BCL6
Background The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Synonyms: B-cell lymphoma 6 protein,BCL6,BCL5, LAZ3, ZBTB27, ZNF51
Molecular Weight 78846 Da
Gene ID 604
UniProt P41182
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Cancer, Transcription Factors, Signaling, Chromatin, Cell Structure
Application Notes WB = 1:1000-16000, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Buffer Crude ascites with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-B-Cell CLL/lymphoma 6 (BCL6) (C-Term), (AA 676-704) antibody Confocal immunofluorescent analysis of BCL6 Antibody (C-term) (ascites) with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).
anti-B-Cell CLL/lymphoma 6 (BCL6) (C-Term), (AA 676-704) antibody (2) BCL6 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the BCL6 antibody detected the BCL6 protein (arrow).
Background publications Ramachandrareddy, Bouska, Shen et al.: "BCL6 promoter interacts with far upstream sequences with greatly enhanced activating histone modifications in germinal center B cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 26, pp. 11930-5, 2010 (PubMed).

Yang, Huang, Chatterjee et al.: "A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription." in: The Journal of biological chemistry, Vol. 285, Issue 39, pp. 29760-9, 2010 (PubMed).

Lai, Fatemi, Dhasarathy et al.: "DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas." in: The Journal of experimental medicine, Vol. 207, Issue 9, pp. 1939-50, 2010 (PubMed).

Chang, Vlad, DAgati et al.: "BCL6 is required for differentiation of Ig-like transcript 3-Fc-induced CD8+ T suppressor cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 10, pp. 5714-22, 2010 (PubMed).

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