Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1) antibody

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Antigen
Synonyms npm4, npm, B23, NPM, NO38, B23NP, Npm, CG7917, CRP1, Crp1, Dmel\\CG7917, dNLP, dNLP-S, p22
Reactivity
Human, Primate
(218), (121), (119), (50), (49), (42), (15), (10), (7), (2), (2), (1), (1), (1)
Host
Mouse
(172), (63), (7), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(10), (7), (6), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (2), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(191), (104), (70), (64), (62), (40), (39), (36), (18), (10), (3)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN659200
330.00 $
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Immunogen Purified recombinant fragment of human NPM expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of human NPM expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name Nucleophosmin
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 32575 DA
Gene ID 12406
NCBI Accession NP_954654
UniProt P06748
Research Area Ubiquitin-related antibodies, Translation Factors, Phospho-specific antibodies, Cancer, Signaling, Chromatin, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000, Immunohistochemistry: = 1:200 - 1000.
Comment

Background: Nucleophosmin (NPM), also named B23 or NO38, is a major nucleolar protein which is 20 times more abundant in tumor or proliferating cells than in normal resting cells. NPM has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication and molecular chaperoning activities . The NPM is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Morris, Kirstein, Valentine et al.: "Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma." in: Science (New York, N.Y.), Vol. 263, Issue 5151, pp. 1281-4, 1994 (PubMed).

Yoneda-Kato, Look, Kirstein et al.: "The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1." in: Oncogene, Vol. 12, Issue 2, pp. 265-75, 1996 (PubMed).

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