B-Cell CLL/lymphoma 10 (BCL10) antibody

Antigen: B-Cell CLL/lymphoma 10 (BCL10)

Synonyms: CLAP, mE10, CIPER, c-E10, CARMEN, ME10, cE10, BCL-10, C81403, AI132454, BCL10, MGC108338

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN659202

Additional Information

Alternative name: BCL-10

Gene ID: 8915

UniProt: O95999, NP_003912.1

Immunogen: Purified recombinant fragment of human BCL-10 expressed in E. Coli.

Isotype: IgG1

Description: Other names: CLAP, Me10, CIPER, c-E10, CARMEN

Characteristics: Mouse Monoclonal antibody to BCL-10

Specificity: Purified recombinant fragment of human BCL-10 expressed in E. Coli.

Molecular Weight: 26252 DA

Comments:

Background: Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Application Details

Application Notes: The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunohistochemistry: ~~ 1:200 - 1000. Immunofluorescence: ~~ 1:200 - 1000. Flow cytometry: ~~ 1:200 - 400.

Buffer: Purified recombinant fragment of human BCL-10 expressed in E. Coli.

Storage: BCL-10 Antibody can be stored at 4?, for long term storage, store at -20?.

Research Area: Apoptosis/Necrosis, Phospho-specific antibodies, Cell Structure, Cancer, Signaling, Chromatin

Restrictions: For Research Use only

Publications

Product: Willis, Jadayel, Du et al.: "Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types." in: Cell, Vol. 96, Issue 1, pp. 35-45, 1999 (PubMed).

Wang, Guo, Huang et al.: "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B." in: The Journal of biological chemistry, Vol. 276, Issue 24, pp. 21405-9, 2001 (PubMed).

Lucas, Yonezumi, Inohara et al.: "Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway." in: The Journal of biological chemistry, Vol. 276, Issue 22, pp. 19012-9, 2001 (PubMed).