B-Cell CLL/lymphoma 10 (BCL10) antibody
| Antigen | B-Cell CLL/lymphoma 10 (BCL10) |
| Synonyms | CLAP, mE10, CIPER, c-E10, CARMEN, ME10, cE10, BCL-10, C81403, AI132454, BCL10, MGC108338 |
| Clonality | Monoclonal |
| Host |
Alternatives Mouse |
| Reactivity |
Alternatives Human |
| Conjugate |
Alternatives Un-conjugated |
| Application |
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA |
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3 references available |
| Certificates | ISO 9001:2008 |
| Catalog no. | ABIN659202 |
| Quantity | 0.1mg |
| Price | 330.00 $ Plus shipping costs $45.00 |
| Shipping to |
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| Availability | Will be delivered in 2 to 3 Business Days |
Additional Information
| Alternative name | BCL-10 |
| Gene ID | 8915 |
| UniProt | O95999, NP_003912.1 |
| Immunogen | Purified recombinant fragment of human BCL-10 expressed in E. Coli. |
| Isotype | IgG1 |
| Description | Other names: CLAP, Me10, CIPER, c-E10, CARMEN |
| Characteristics | Mouse Monoclonal antibody to BCL-10 |
| Specificity | Purified recombinant fragment of human BCL-10 expressed in E. Coli. |
| Molecular Weight | 26252 DA |
| Comments |
Background: Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. |
Application Details
| Application Notes | The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunohistochemistry: ~~ 1:200 - 1000. Immunofluorescence: ~~ 1:200 - 1000. Flow cytometry: ~~ 1:200 - 400. |
| Buffer | Purified recombinant fragment of human BCL-10 expressed in E. Coli. |
| Storage | BCL-10 Antibody can be stored at 4?, for long term storage, store at -20?. |
| Research Area | Apoptosis/Necrosis, Phospho-specific antibodies, Cell Structure, Cancer, Signaling, Chromatin |
| Restrictions | For Research Use only |
Publications
| Product |
Willis, Jadayel, Du et al.: "Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types." in: Cell, Vol. 96, Issue 1, pp. 35-45, 1999 (PubMed).
Wang, Guo, Huang et al.: "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B." in: The Journal of biological chemistry, Vol. 276, Issue 24, pp. 21405-9, 2001 (PubMed). Lucas, Yonezumi, Inohara et al.: "Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway." in: The Journal of biological chemistry, Vol. 276, Issue 22, pp. 19012-9, 2001 (PubMed). |




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