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Details for Product No. ABIN659208

Interferon gamma (IFNG) antibody

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Antigen
Synonyms IFG, IFI, Ifg, IFN-g, IFNG2, IFN-gamma, IFN-G
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), ELISA
Pubmed 2 references available
Catalog no. ABIN659208
Quantity 0.1 mg
Price
330.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Purified recombinant fragment of human IFN-? expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of human IFN-? expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name IFN-gamma
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 19348 DA
Gene ID 12406
UniProt NP_000610.2, P01579
Research Area Cell Signaling, Cell Structure
Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000.
Comment

Background: Interferon-? (IFN-?) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN-? strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Tsubota, Fukagawa, Fujihara et al.: "Regulation of human leukocyte antigen expression in human conjunctival epithelium." in: Investigative ophthalmology & visual science, Vol. 40, Issue 1, pp. 28-34, 1999 (PubMed).

Takayanagi, Ogasawara, Hida et al.: "T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma." in: Nature, Vol. 408, Issue 6812, pp. 600-5, 2000 (PubMed).

Alternatives for antigen "Interferon gamma (IFNG)", type "Antibodies"
Hosts (310), (178), (105), (23), (6), (3), (2), (1)
Reactivities (359), (165), (84), (27), (25), (17), (10), (10), (9), (8), (8), (8), (6), (4), (4), (4), (4), (4), (3), (1), (1), (1)
Applications (385), (304), (178), (72), (65), (60), (51), (37), (35), (30), (29), (28), (25), (17), (12), (11), (8), (7), (6), (6), (5), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Conjugates (85), (51), (24), (11), (9), (6), (5), (5), (5), (3), (3), (3), (3), (3), (3), (2), (2), (1)
Epitopes (9), (9), (6), (3), (3), (2), (2), (2), (2), (1), (1)
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