|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Chemokine (C-C Motif) Ligand 2 (CCL2) antibody
|Synonyms||HC11, MCAF, MCP1, MCP-1, SCYA2, GDCF-2, SMC-CF, HSMCR30, MGC9434, JE, Scya2, Sigje, AI323594, CCL2, DKFZp469C111|
Alternatives Western Blotting (WB), ELISA
|3 references available|
|Price||330.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||Purified recombinant fragment of human MCP-1 expressed in E. Coli.|
|Description||Other names: MCP1|
|Characteristics||Mouse Monoclonal antibody to MCP-1|
|Specificity||Purified recombinant fragment of human MCP-1 expressed in E. Coli.|
|Molecular Weight||11025 DA|
Background: Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.
|Application Notes||The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000.|
|Buffer||Purified recombinant fragment of human MCP-1 expressed in E. Coli.|
|Storage||MCP-1 Antibody can be stored at 4?, for long term storage, store at -20?.|
|Research Area||Cell Structure|
|Restrictions||For Research Use only|
Yoshimura, Leonard: "Human monocyte chemoattractant protein-1 (MCP-1)." in: Advances in experimental medicine and biology, Vol. 305, pp. 47-56, 1992 (PubMed).
Rollins, Morton, Ledbetter et al.: "Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus." in: Genomics, Vol. 10, Issue 2, pp. 489-92, 1991 (PubMed).
Yoshimura, Yuhki, Moore et al.: "Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE." in: FEBS letters, Vol. 244, Issue 2, pp. 487-93, 1989 (PubMed).