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Chemokine (C-C Motif) Ligand 2 (CCL2) antibody

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(318), (112), (89), (18), (12), (12), (9), (8), (7), (7), (6), (5), (5), (2), (1)
(281), (152), (30), (9), (9), (8), (6)
(67), (37), (22), (12), (6), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Western Blotting (WB)
(345), (289), (88), (64), (56), (56), (41), (40), (32), (26), (26), (24), (8), (6), (5), (5), (4), (3), (3), (3), (3), (2), (2), (1)
Pubmed 3 references available
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Quantity 0.1 mg
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Immunogen Purified recombinant fragment of human MCP-1 expressed in E. Coli.
Isotype IgG1 kappa
Specificity Purified recombinant fragment of human MCP-1 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MCP-1 (CCL2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 11025 DA
Gene ID 12406
NCBI Accession NP_002973
UniProt P13500
Research Area Cell Structure
Application Notes Western Bloting: = 1:500 - 2000.

Background: Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine-beta family of cytokines. The protein is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. It may play a inprotant role in the initiation and/or progression of pulmonary hypertension (PH). Blockade of a systemic MCP-1 signal pathway in vivo may prevent PH.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Yoshimura, Yuhki, Moore et al.: "Human monocyte chemoattractant protein-1 (MCP-1). Full-length cDNA cloning, expression in mitogen-stimulated blood mononuclear leukocytes, and sequence similarity to mouse competence gene JE." in: FEBS letters, Vol. 244, Issue 2, pp. 487-93, 1989 (PubMed).

Rollins, Morton, Ledbetter et al.: "Assignment of the human small inducible cytokine A2 gene, SCYA2 (encoding JE or MCP-1), to 17q11.2-12: evolutionary relatedness of cytokines clustered at the same locus." in: Genomics, Vol. 10, Issue 2, pp. 489-92, 1991 (PubMed).

Yoshimura, Leonard: "Human monocyte chemoattractant protein-1 (MCP-1)." in: Advances in experimental medicine and biology, Vol. 305, pp. 47-56, 1992 (PubMed).

Catalog No. ABIN659213

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