Apolipoprotein A-V (APOA5) antibody

Details for Product No. ABIN659238
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Antigen
Synonyms APOA5, MGC140487, rap3, apoav, apoa-v, APOAV, RAP3, apo-AV, apoA-V, 1300007O05Rik, Apoav
Reactivity
Human
(98), (14), (14), (12), (8), (1)
Host
Mouse
(58), (41), (4)
Clonality
Monoclonal
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(78), (76), (11), (10), (9), (6), (4), (1), (1)
Pubmed 1 reference available
Quantity 2 x 0.1 mg
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Catalog No. ABIN659238
583.00 $
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Immunogen Purified recombinant fragment of human Apoa5 expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of human Apoa5 expressed in E. Coli.
Alternative Name APOA5
Background Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglycerides, whereas a knock-in model with human ApoA5 produced 50ヨ70% lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor- agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Despite these compelling molecular biology data, relatively little is known about ApoA5 protein in human serum. This antibody pair detected recombinant apoa5 protein in sandwich ELISA format and could be potential reagents for the development of clinical diagnostic kits.
Synonyms: RAP3, APOAV, APOA-V, MGC126836, MGC126838
Molecular Weight 41213 DA
Gene ID 116519
UniProt Q6Q788, NP_443200.2
Research Area Phospho-specific antibodies, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000.
Comment

Background: Apolipoprotein A5 (ApoA5) is fast gaining attention as a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model produced an approximately four fold increase in serum triglycerides, whereas a knock-in model with human ApoA5 produced 50ヨ70% lower concentrations of mouse serum triglycerides. In addition, peroxisome proliferator-activated receptor- agonists, which are used clinically to lower serum triglyceride concentrations, cause increased ApoA5 mRNA expression. Despite these compelling molecular biology data, relatively little is known about ApoA5 protein in human serum. This antibody pair detected recombinant apoa5 protein in sandwich ELISA format and could be potential reagents for the development of clinical diagnostic kits.

Restrictions For Research Use only
Storage 4 °C
Storage Comment APOA5 Antibody can be stored at 4°C, for long term storage, store at -20°C.
Background publications Pennacchio, Olivier, Hubacek et al.: "An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing." in: Science (New York, N.Y.), Vol. 294, Issue 5540, pp. 169-73, 2001 (PubMed).

Validation Images
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