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MAP2K4 antibody (Mitogen-Activated Protein Kinase Kinase 4)

Details for Product anti-MAP2K4 Antibody No. ABIN659283, Supplier: Login to see New
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(317), (146), (114), (8), (5), (4), (4), (4), (2), (2)
(291), (39)
This MAP2K4 antibody is un-conjugated
(12), (12), (11), (8), (8), (8), (5), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (IHC)
(213), (147), (113), (66), (46), (21), (17), (15), (14), (11), (4), (3), (2)
Pubmed 3 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Purified recombinant fragment of MAP2K4 expressed in E. Coli.
Isotype IgM
Specificity Purified recombinant fragment of MAP2K4 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MAP2K4 (MAP2K4 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 44288 DA
Gene ID 12406
NCBI Accession NP_003001
UniProt P45985
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Signaling, Chromatin, Cell Structure
Pathways MAPK Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes Immunohistochemistry: = 1:200 - 1000

Background: MAP2K4(mitogen-activated protein kinase kinase 4), which is located on chromosome 17p11.2, with 399-amino acid protein (about 45 kDa), belongs to the family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. MEK-4 (also called MEK4/MKK4) activates both p38 and JNK MAP kinases. MKK4 is a central mediator in the stress activated protein kinase signaling pathway that responds to a number of cellular and environmental stressors. By phosphorylating MAP kinases such as JNK,MKK4 can ultimately transmit stress signals to nuclear transcription factors that mediate various processes including proliferation, apoptosis, and differentiation. Its distinct biological functions have been identified for MKK4 including a role in development, hepatogenesis, and metastasis suppression.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Kim, Vander Griend, Yang et al.: "Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers." in: Cancer research, Vol. 61, Issue 7, pp. 2833-7, 2001 (PubMed).

Cuenda: "Mitogen-activated protein kinase kinase 4 (MKK4)." in: The international journal of biochemistry & cell biology, Vol. 32, Issue 6, pp. 581-7, 2000 (PubMed).

Crews, Alessandrini, Erikson: "The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product." in: Science (New York, N.Y.), Vol. 258, Issue 5081, pp. 478-80, 1992 (PubMed).

Catalog No. ABIN659283

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