|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) antibody
Alternatives Immunohistochemistry (IHC), ELISA
|3 references available|
|Price||330.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||Purified recombinant fragment of MAP2K4 expressed in E. Coli.|
|Description||Other names: MAP2K4|
|Characteristics||Mouse Monoclonal Antibody to MAP2K4|
|Specificity||Purified recombinant fragment of MAP2K4 expressed in E. Coli.|
|Molecular Weight||44288 DA|
Background: MAP2K4(mitogen-activated protein kinase kinase 4), which is located on chromosome 17p11.2, with 399-amino acid protein (about 45 kDa), belongs to the family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. MEK-4 (also called MEK4/MKK4) activates both p38 and JNK MAP kinases. MKK4 is a central mediator in the stress activated protein kinase signaling pathway that responds to a number of cellular and environmental stressors. By phosphorylating MAP kinases such as JNK,MKK4 can ultimately transmit stress signals to nuclear transcription factors that mediate various processes including proliferation, apoptosis, and differentiation. Its distinct biological functions have been identified for MKK4 including a role in development, hepatogenesis, and metastasis suppression.
|Synonyms||JNKK, MEK4, MKK4, SEK1, JNKK1, SERK1, MAPKK4, PRKMK4, Sek1, Serk1, map2k4a, MGC136500, zgc:136500, jnkk, mek4, mkk4, sek1, jnkk1, serk1, xmek2, mapkk4, prkmk4, 142758_at, CT27508, D-MKK4, DMKK4, JNKK2, Mpk4, SEK1/MKK4, DmelCG9738, CG9738, CT38386, DmelCG12798, CG12798, DmelCR12798|
|Application Notes||[The suggested dilution is:, ELISA: ~~ 1:10000., Immunohistochemistry: ~~ 1:200 - 1000.]|
|Buffer||Purified recombinant fragment of MAP2K4 expressed in E. Coli.|
|Storage||MAP2K4 Antibody can be stored at 4?, for long term storage, store at -20?.|
|Research Area||Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Signaling, Chromatin, Cell Structure|
|Restrictions||For Research Use only|
Crews, Alessandrini, Erikson: "The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product." in: Science (New York, N.Y.), Vol. 258, Issue 5081, pp. 478-80, 1992 (PubMed).
Cuenda: "Mitogen-activated protein kinase kinase 4 (MKK4)." in: The international journal of biochemistry & cell biology, Vol. 32, Issue 6, pp. 581-7, 2000 (PubMed).
Kim, Vander Griend, Yang et al.: "Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers." in: Cancer research, Vol. 61, Issue 7, pp. 2833-7, 2001 (PubMed).