S100 Calcium Binding Protein A1 (S100A1) antibody

Antigen: S100 Calcium Binding Protein A1 (S100A1)

Synonyms: S100, S100A, S100-alpha, S100a1, S100A1, MGC159706, DKFZp468K0511

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN659300

Additional Information

Alternative name: S100A1

Gene ID: 6271

UniProt: NP_006262.1, P23297

Immunogen: Purified recombinant fragment of S100A1 expressed in E. Coli.

Isotype: IgG1

Description: Other names: S100, S100A, S100-alpha, S100A1

Characteristics: Mouse Monoclonal Antibody to S100A1

Specificity: Purified recombinant fragment of S100A1 expressed in E. Coli.

Molecular Weight: 10546 DA

Comments:

Background: S100 calcium binding protein A1 (S100-alpha/ S100A1), it is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.

Application Details

Application Notes: The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunohistochemistry: ~~ 1:200 - 1000.

Buffer: Purified recombinant fragment of S100A1 expressed in E. Coli.

Storage: S100A1 Antibody can be stored at 4?, for long term storage, store at -20?.

Restrictions: For Research Use only

Publications

Product: Pingerelli, Mizukami, Wagner et al.: "Investigation of the Ca2(+)-dependent interaction of trifluoperazine with S100a: a 19F NMR and circular dichroism study." in: Journal of protein chemistry, Vol. 9, Issue 2, pp. 169-75, 1990 (PubMed).

Hoyaux, Decaestecker, Heizmann et al.: "S100 proteins in Corpora amylacea from normal human brain." in: Brain research, Vol. 867, Issue 1-2, pp. 280-8, 2000 (PubMed).

Koenig, Wojcieszyn, Weeks et al.: "Expression of S100a, vimentin, NSE, and melan A/MART-1 in seven canine melanoma cells lines and twenty-nine retrospective cases of canine melanoma." in: Veterinary pathology, Vol. 38, Issue 4, pp. 427-35, 2001 (PubMed).