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Details for Product No. ABIN659300

S100 Calcium Binding Protein A1 (S100A1) antibody

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Synonyms S100, S100A, S100-alpha, AI266795, S100a, S100a1, S100A1, DKFZp468K0511
»Alternatives Human
»Alternatives Mouse
Clonality Monoclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
Pubmed 3 references available
Catalog no. ABIN659300
Quantity 0.1 mg
357.50 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of S100A1 expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of S100A1 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name S100A1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 10546 DA
Gene ID 12406
UniProt NP_006262.1, P23297
Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunohistochemistry: ~~ 1:200 - 1000.

Background: S100 calcium binding protein A1 (S100-alpha/ S100A1), it is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Pingerelli, Mizukami, Wagner et al.: "Investigation of the Ca2(+)-dependent interaction of trifluoperazine with S100a: a 19F NMR and circular dichroism study." in: Journal of protein chemistry, Vol. 9, Issue 2, pp. 169-75, 1990 (PubMed).

Hoyaux, Decaestecker, Heizmann et al.: "S100 proteins in Corpora amylacea from normal human brain." in: Brain research, Vol. 867, Issue 1-2, pp. 280-8, 2000 (PubMed).

Koenig, Wojcieszyn, Weeks et al.: "Expression of S100a, vimentin, NSE, and melan A/MART-1 in seven canine melanoma cells lines and twenty-nine retrospective cases of canine melanoma." in: Veterinary pathology, Vol. 38, Issue 4, pp. 427-35, 2001 (PubMed).

Alternatives for antigen "S100 Calcium Binding Protein A1 (S100A1)", type "Antibodies"
Hosts (95), (74), (5), (1)
Reactivities (124), (75), (41), (41), (11), (8), (8), (4), (2), (1)
Applications (89), (75), (61), (44), (26), (19), (14), (9), (6), (6), (6), (5), (4), (2), (2), (1), (1)
Conjugates (5), (4), (1), (1), (1), (1), (1)
Epitopes (6), (4), (2), (2), (2), (1), (1)