S100 Calcium Binding Protein A1 (S100A1) antibody

Details for Product No. ABIN659300
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Antigen
Synonyms S100a1, S100A1, DKFZp468K0511, S100, S100-alpha, S100A, AI266795, S100a, NEF, S100-B, S100beta
Reactivity
Human
(141), (86), (52), (48), (12), (12), (11), (6), (2), (1)
Host
Mouse
(115), (77), (7), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(7), (6), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(99), (93), (81), (54), (32), (24), (20), (10), (7), (6), (4), (2), (1), (1), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN659300
357.50 $
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Immunogen Purified recombinant fragment of S100A1 expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of S100A1 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name S100A1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 10546 DA
Gene ID 12406
NCBI Accession NP_006262
UniProt P23297
Application Notes Western Bloting: = 1:500 - 2000, Immunohistochemistry: = 1:200 - 1000.
Comment

Background: S100 calcium binding protein A1 (S100-alpha/ S100A1), it is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Pingerelli, Mizukami, Wagner et al.: "Investigation of the Ca2(+)-dependent interaction of trifluoperazine with S100a: a 19F NMR and circular dichroism study." in: Journal of protein chemistry, Vol. 9, Issue 2, pp. 169-75, 1990 (PubMed).

Hoyaux, Decaestecker, Heizmann et al.: "S100 proteins in Corpora amylacea from normal human brain." in: Brain research, Vol. 867, Issue 1-2, pp. 280-8, 2000 (PubMed).

Koenig, Wojcieszyn, Weeks et al.: "Expression of S100a, vimentin, NSE, and melan A/MART-1 in seven canine melanoma cells lines and twenty-nine retrospective cases of canine melanoma." in: Veterinary pathology, Vol. 38, Issue 4, pp. 427-35, 2001 (PubMed).

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