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V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT) antibody

Antigen

V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT)
Synonyms PBT, SCFR, C-Kit, CD117, W, Bs, Fdc, Ssm, SCO1, SCO5, SOW3, c-KIT, Tr-kit, Gsfsco1, Gsfsco5, Gsfsow3, c-kit, kit-A, XKrk1, KIT, MGF, LOC100221238, C-KIT
Clonality Monoclonal
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN659302
Quantity 0.1ml
Price 357.50 $   Plus shipping costs $45.00
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Additional Information
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Alternative name C-Kit
Gene ID 3815
UniProt NP_001087241.1, P10721
Immunogen Purified recombinant fragment of C-kit expressed in E. Coli.
Isotype IgG1
Description Other names: PBT, SCFR, C-Kit, CD117, KIT
Characteristics Mouse Monoclonal Antibody to C-Kit
Specificity Purified recombinant fragment of C-kit expressed in E. Coli.
Molecular Weight 109865 DA
Comments

Background: C-kit (CD117, 145kDa) functions as a tyrosine kinase receptor which becomes activated upon binding of its ligand SCF (stem-cell factor), the C-kit gene encodes the human homolog of the proto-oncogene c-kit. which was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT is a type 3 transmembrane receptor for MGF (mast cell growth factor). Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism.

Application Details
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Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunohistochemistry: ~~ 1:200 - 1000.
Buffer Purified recombinant fragment of C-kit expressed in E. Coli.
Storage C-Kit Antibody can be stored at 4?, for long term storage, store at -20?.
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Signaling, Chromatin
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product Nakai, Nonomura, Oka et al.: "KIT (c-kit oncogene product) pathway is constitutively activated in human testicular germ cell tumors." in: Biochemical and biophysical research communications, Vol. 337, Issue 1, pp. 289-96, 2005 (PubMed).

Mojica, Saxena, Starostik et al.: "CD117+ small cell lung cancer lacks the asp 816-->val point mutation in exon 17." in: Histopathology, Vol. 47, Issue 5, pp. 517-22, 2005 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT)", type "Antibodies"
Hosts Rabbit (109), Mouse (61), Rat (45)
Reactivities Human (158), Mouse (Murine) (90), Rat (Rattus) (45), Cow (Bovine) (29), Dog (Canine) (21), Pig (Porcine) (16), Horse (Equine) (15), Primate (12), Chicken (8), Monkey (3)
Applications Flow Cytometry (FACS) (88), Western Blotting (WB) (52), Immunofluorescence (IF) (40), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (40), ELISA (31), Immunohistochemistry (IHC) (31), Immunohistochemistry (Frozen Sections) (IHC (fro)) (23), Immunoprecipitation (IP) (18), Immunocytochemistry (ICC) (17), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (4), Functional Studies (Func) (2), Dot Blot (DB) (1), Neutralization (Neut) (1)
Conjugates PE (20), FITC (14), Biotin (12), APC (5), Alexa Fluor 350 (5), Alexa Fluor 488 (5), Alexa Fluor 555 (5), Alexa Fluor 647 (5), PE,Cy5.5 (5), APC,Cy7 (2), Cy5 (2), SPRD (2), PE-Cy5 (1), PerCP (1), PerCP-Cy5.5 (1), RPE (1)
Epitopes pTyr721 (12), pTyr936 (10), pSer741 (5), pTyr703 (5), C-Term (4), Extracellular Domain (4), pSer721 (4), Tyr721 (3), Tyr936 (3), pTyr719 (2), N-Term (1), pSer27 (1), pSer392 (1), pSer740 (1), pY721 (1), pY936 (1)