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Insulin-Like Growth Factor 1 Receptor (IGF1R) antibody

Antigen

Insulin-Like Growth Factor 1 Receptor (IGF1R)
Synonyms IGFR, CD221, IGFIR, JTK13, MGC18216, MGC142170, MGC142172, IGFIRC, IGF1R, IGF-1R, DKFZp469I0618, xIGFR, xigf1r, xIGF-1R, hyft, D930020L01, A330103N21Rik
Clonality Monoclonal
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN659318
Quantity 0.1ml
Price 357.50 $   Plus shipping costs $45.00
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Additional Information
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Alternative name IGF1R
Gene ID 3480
UniProt NP_000866.1, P08069
Immunogen Purified recombinant fragment of IGF1R expressed in E. Coli.
Isotype IgG2b
Description Other names: IGF1R
Characteristics Mouse Monoclonal Antibody to IGF1R
Specificity Purified recombinant fragment of IGF1R expressed in E. Coli.
Molecular Weight 154793 DA
Comments

Background: IGF1R (insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.

Application Details
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Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunohistochemistry: ~~ 1:200 - 1000.
Buffer Purified recombinant fragment of IGF1R expressed in E. Coli.
Storage IGF1R Antibody can be stored at 4?, for long term storage, store at -20?.
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Signaling, Chromatin, Cell Structure
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product Adams, Epa, Garrett et al.: "Structure and function of the type 1 insulin-like growth factor receptor." in: Cellular and molecular life sciences : CMLS, Vol. 57, Issue 7, pp. 1050-93, 2000 (PubMed).

Scheidegger, Cenni, Picard et al.: "Estradiol decreases IGF-1 and IGF-1 receptor expression in rat aortic smooth muscle cells. Mechanisms for its atheroprotective effects." in: The Journal of biological chemistry, Vol. 275, Issue 49, pp. 38921-8, 2001 (PubMed).

Baserga: "The contradictions of the insulin-like growth factor 1 receptor." in: Oncogene, Vol. 19, Issue 49, pp. 5574-81, 2000 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Insulin-Like Growth Factor 1 Receptor (IGF1R)", type "Antibodies"
Hosts Rabbit (136), Mouse (88), Goat (1)
Reactivities Human (224), Mouse (Murine) (105), Rat (Rattus) (102), Cow (Bovine) (53), Dog (Canine) (52), Pig (Porcine) (52), Sheep (Ovine) (41), Chicken (30), Horse (Equine) (28), Rabbit (2), Cat (Feline) (1), Xenopus laevis (1), Zebrafish (1)
Applications Western Blotting (WB) (111), Immunofluorescence (IF) (70), ELISA (61), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (47), Immunoprecipitation (IP) (37), Immunohistochemistry (IHC) (27), Flow Cytometry (FACS) (18), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (9), Functional Studies (Func) (8), Immunocytochemistry (ICC) (6), Immunoelectron Microscopy (IEM) (3), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Dot Blot (DB) (1), Neutralization (Neut) (1)
Conjugates Alexa Fluor 350 (7), Alexa Fluor 488 (7), Alexa Fluor 555 (7), Alexa Fluor 647 (7), PE (6), PE,Cy5.5 (6), Biotin (4), Cy3 (3), Cy5 (3), Cy5.5 (3), Cy7 (3), FITC (3), Gold (3), HRP (3), APC (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy7 (2), RPE (2), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1), Un-conjugated (1)
Epitopes pTyr980 (8), C-Term (7), pTyr1161 (6), pTyr1280 (5), pTyr1166,pTyr1165 (4), AA 1323-1337 (2), AA 283-440 (2), AA 514-586 (2), Chain alpha (2), N-Term (2), pTyr1165, pTyr1166 (2), pTyr1316 (2), AA 1215-1368 (1), AA 1264-1367 (1), Center (1), Internal Region (1), N-Term,Lys66 (1), Tyr1165, Tyr1166 (1), Tyr1280 (1), pSer15 (1), pThr176 (1), pTyr1131, pTyr1146 (1), pTyr1131, pTyr1158 (1), pTyr1131, pTyr1185 (1), pTyr1135 (1), pTyr1135, pTyr1136, pTyr1162, pTyr1163 (1), pTyr1158 (1), pTyr1158, pTyr1162, pTyr1163 (1), pTyr1165 (1), pTyr1346 (1)