K(lysine) Acetyltransferase 5 (KAT5) antibody

Details for Product No. ABIN659321
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Antigen
Synonyms
AI839539, CPLA2, Htatip, Htatip1, PLIP, Tip55, Tip60, ESA1, HTATIP, HTATIP1, TIP, TIP60, ZC2HC5, cPLA2, im:6908768, wu:fb55b08, zgc:110752, 6121, CG6121, DmEG0007.7, Dmel/TIP60, Dmel\\CG6121, Dmel\\TI ... show more
AI839539, CPLA2, Htatip, Htatip1, PLIP, Tip55, Tip60, ESA1, HTATIP, HTATIP1, TIP, TIP60, ZC2HC5, cPLA2, im:6908768, wu:fb55b08, zgc:110752, 6121, CG6121, DmEG0007.7, Dmel/TIP60, Dmel\\CG6121, Dmel\\TIP60, EG0007.7, EG:EG0007.7, dTIP60, dTip60, dmHAG405 show less
Reactivity
Human
(97), (51), (38), (5), (4), (4), (2), (1), (1), (1), (1), (1), (1)
Host
Mouse
(80), (18)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(65), (49), (35), (11), (10), (8), (7), (5), (4), (3)
Pubmed 2 references available
Catalog no. ABIN659321
Quantity 0.1 mg
Price
357.50 $   Plus shipping costs $45.00
Options
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Purified recombinant fragment of human TIP60 expressed in E. Coli.
Isotype IgG2b
Specificity Purified recombinant fragment of human TIP60 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TIP60
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 58582 DA
Gene ID 12406
UniProt Q92993, NP_874368.1
Research Area Ubiquitin-related antibodies, Translation Factors, Phospho-specific antibodies, Cell Cycle, Transcription Factors, Signaling, Chromatin, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000, Immunohistochemistry: = 1:200 - 1000.
Comment

Background: HTATIP (HIV-1 Tat interacting protein TIP60, about 60kDa) belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. In addition to the growing number of post-translational histone modifications regulating chromatin structure, cells can also exchange canonical histones with variant histones that can directly or indirectly modulate chromatin structure. There are five major variants of histone H2A: canonical H2A (most abundant), H2A.X, MacroH2A, H2ABbd and H2A.Z. Histone H2A.Z, the most conserved variant across species, functions as both a positive and negative regulator of transcription and is important for chromosome stability. Several homologous protein complexes, such as SWR-C, TIP60 and SRCAP (mammals), have been shown to catalyze the ATP-dependent exchange of H2A.Z for H2A in the nucleosome. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Mizuguchi, Shen, Landry et al.: "ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex." in: Science (New York, N.Y.), Vol. 303, Issue 5656, pp. 343-8, 2004 (PubMed).

Raisner, Madhani: "Patterning chromatin: form and function for H2A.Z variant nucleosomes." in: Current opinion in genetics & development, Vol. 16, Issue 2, pp. 119-24, 2006 (PubMed).

Hosts (80), (18)
Reactivities (97), (51), (38), (5), (4), (4), (2), (1), (1), (1), (1), (1), (1)
Applications (65), (49), (35), (11), (10), (8), (7), (5), (4), (3)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (8), (7), (7), (5), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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