Feline Sarcoma Oncogene (FES) antibody

Details for Product No. ABIN659326
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Antigen
Synonyms FES, c-fps, FPS, AI586313, BB137047, c-fes, RGD1564385
Reactivity
Human
(81), (29), (18), (12), (12), (1), (1), (1)
Host
Mouse
(48), (32), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(70), (45), (17), (10), (9), (3), (3), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN659326
423.50 $
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Immunogen Purified recombinant fragment of FES expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of FES expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FES
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 93497 DA
Gene ID 12406
NCBI Accession NP_001996
UniProt P07332
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Signaling, Chromatin, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000.
Comment

Background: FES (feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Delfino, Stevenson, Smithgall: "A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer." in: The Journal of biological chemistry, Vol. 281, Issue 13, pp. 8829-35, 2006 (PubMed).

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