Feline Sarcoma Oncogene (FES) antibody

Antigen: Feline Sarcoma Oncogene (FES)

Synonyms: RGD1564385, FES, FPS, c-fes, AI586313, BB137047, c-fps

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN659328

Additional Information

Alternative name: FES

Gene ID: 2242

UniProt: P07332, NP_001996.1

Immunogen: Purified recombinant fragment of FES expressed in E. Coli.

Isotype: IgG1

Description: Other names: FPS

Characteristics: Mouse Monoclonal Antibody to FES

Specificity: Purified recombinant fragment of FES expressed in E. Coli.

Molecular Weight: 93497 DA

Comments:

Background: FES (feline sarcoma oncogene) and Fer are the only two members of a unique family of cytoplasmic protein tyrosine kinases. FES and Fer contain a central Src homology-2 (SH2) domain and a carboxy-terminal tyrosine kinase catalytic domain. They are structurally distinguished from other members of cytoplasmic protein tyrosine kinase subfamilies by the presence of amino-terminal Fer/CIP4 homology and coiled-coil domains. FES was originally identified as an oncogene from avian and feline retroviruses. Human c-Fes has been implicated in myeloid, vascular endothelial and neuronal cell differentiation. FES has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Mutations may activate the FES kinase and thereby contribute to cancer. However, recent data strongly suggests that the c-FES protein-tyrosine kinase is a tumor suppressor rather than a dominant oncogene in colorectal cancer.

Application Details

Application Notes: The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000.

Buffer: Purified recombinant fragment of FES expressed in E. Coli.

Storage: FES Antibody can be stored at 4?, for long term storage, store at -20?.

Research Area: Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Chromatin, Signaling, Cell Structure

Restrictions: For Research Use only

Publications

Product: Delfino, Stevenson, Smithgall: "A growth-suppressive function for the c-fes protein-tyrosine kinase in colorectal cancer." in: The Journal of biological chemistry, Vol. 281, Issue 13, pp. 8829-35, 2006 (PubMed).