LPP antibody

Antigen: LPP

Clonality: Monoclonal

Host: Mouse

Reactivity: Human, Primate, Hamster

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN659355

Additional Information

Gene ID: 4026

UniProt: NP_005569.1, Q93052

Immunogen: Purified recombinant fragment of human LPP expressed in E. Coli.

Isotype: IgG1

Description: Other names: LPP

Characteristics: Mouse Monoclonal Antibody to LPP

Specificity: Purified recombinant fragment of human LPP expressed in E. Coli.

Molecular Weight: 65746 DA

Comments:

Background: LIM domain containing preferred translocation partner in lipoma. The Zyxin family of proteins contains five members, Ajuba, LIMD1, LPP,TRIP6 and Zyxin. LPP (LIM-containing lipoma-preferred partner), a LIM domain-containing scaffolding protein contains three LIM domains at its carboxy terminus, which are preceded by a proline-rich pre-LIM region containing a number of protein interaction domains. LPP, an 80 kDa protein, localizes to sites of cell adhesion, such as focal adhesions and cell-cell contacts,and shuttles to the nucleus where it has transcriptional activation capacity.The human LPP gene maps to chromosomal location 3q28, and preferentially translocates to the HMGIC gene in a subclass of human benign mesenchymal tumors known as lipomas.

Application Details

Application Notes: The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunohistochemistry: ~~ 1:200 - 1000. Immunofluorescence: ~~ 1:200 - 1000.

Buffer: Purified recombinant fragment of human LPP expressed in E. Coli.

Storage: LPP Antibody can be stored at 4?, for long term storage, store at -20?.

Research Area: Translation Factors, Phospho-specific antibodies, Signaling, Chromatin, Cell Structure

Restrictions: For Research Use only

Publications

Product: Petit, Meulemans, Alen et al.: "The tumor suppressor Scrib interacts with the zyxin-related protein LPP, which shuttles between cell adhesion sites and the nucleus." in: BMC cell biology, Vol. 6, Issue 1, pp. 1, 2005 (PubMed).

Zhang, Wolf-Yadlin, Ross et al.: "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules." in: Molecular & cellular proteomics : MCP, Vol. 4, Issue 9, pp. 1240-50, 2005 (PubMed).

von Ahsen, Rogalla, Bullerdiek: "Expression patterns of the LPP-HMGA2 fusion transcript in pulmonary chondroid hamartomas with t(3;12)(q27 approximately 28;q14 approximately 15)." in: Cancer genetics and cytogenetics, Vol. 163, Issue 1, pp. 68-70, 2005 (PubMed).