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EhpB6 antibody

Details for Product No. ABIN659360
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Antigen
Reactivity
Human
(4)
Host
Mouse
(4)
Clonality
Monoclonal
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(4), (4), (3)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN659360
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Purified recombinant fragment of EphB6(aa601-750) expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of EphB6(aa601-750) expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 109273 DA
Gene ID 12406
UniProt O15197, NP_004436.2
Research Area Cell Signaling, Chromatin, Signaling, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000, Immunohistochemistry: = 1:200 - 1000.
Comment

Background: EhpB6: EPH receptor B6. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Luo, Yu, Wu et al.: "EphB6 crosslinking results in costimulation of T cells." in: The Journal of clinical investigation, Vol. 110, Issue 8, pp. 1141-50, 2002 (PubMed).

Freywald, Sharfe, Rashotte et al.: "The EphB6 receptor inhibits JNK activation in T lymphocytes and modulates T cell receptor-mediated responses." in: The Journal of biological chemistry, Vol. 278, Issue 12, pp. 10150-6, 2003 (PubMed).

Fox, Kandpal: "Transcriptional silencing of EphB6 receptor tyrosine kinase in invasive breast carcinoma cells and detection of methylated promoter by methylation specific PCR." in: Biochemical and biophysical research communications, Vol. 340, Issue 1, pp. 268-76, 2005 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN659360
357.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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