V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 (YES1) (AA 10-193) antibody

Details for Product No. ABIN659362
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Antigen
Synonyms YES1, c-yes, hst441, p61-yes, yes, HsT441, P61-YES, Yes, p61-Yes, YES, c-Yes, p60c-yes
Epitope
AA 10-193
(17), (12), (12), (8), (7), (6), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(104), (43), (38), (37), (36), (36), (36), (24), (1), (1)
Host
Mouse
(80), (22), (3)
Clonality
Monoclonal
Conjugate
Un-conjugated
(7), (6), (6), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB)
(75), (50), (30), (20), (18), (8), (4), (4), (3), (3), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
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Catalog No. ABIN659362
423.50 $
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Immunogen Purified recombinant fragment of YES(aa10-193) expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of YES(aa10-193) expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name YES1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 60801 DA
Gene ID 12406
NCBI Accession NP_005424
UniProt P07947
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Chromatin, Signaling, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000.
Comment

Background: YES1, v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1. This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Reinehr, Becker, Höngen et al.: "The Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95." in: The Journal of biological chemistry, Vol. 279, Issue 23, pp. 23977-87, 2004 (PubMed).

Annerén, Cowan, Melton: "The Src family of tyrosine kinases is important for embryonic stem cell self-renewal." in: The Journal of biological chemistry, Vol. 279, Issue 30, pp. 31590-8, 2004 (PubMed).

Rush, Moritz, Lee et al.: "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells." in: Nature biotechnology, Vol. 23, Issue 1, pp. 94-101, 2005 (PubMed).

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