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Details for Product No. ABIN659370

EPH Receptor B3 (EPHB3) antibody

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Antigen
Synonyms ETK2, HEK2, TYRO6, EK10, CEK10, AW456895, Cek10, Etk2, MDK5, Sek4, Tyro6, tck, MGC83457, EPHB3
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
Pubmed 4 references available
Catalog no. ABIN659370
Quantity 0.1 mg
Price
423.50 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of EphB3(aa39-212) expressed in E. Coli.
Isotype IgG2a
Specificity Purified recombinant fragment of EphB3(aa39-212) expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name EphB3
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 110330 DA
Gene ID 12406
UniProt P54753, NP_004434.2
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Signaling, Chromatin, Cell Structure
Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunohistochemistry: ~~ 1:200 - 1000.
Comment

Background: EphB3: EPH receptor B3. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Bergemann, Zhang, Chiang et al.: "Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube." in: Oncogene, Vol. 16, Issue 4, pp. 471-80, 1998 (PubMed).

Zhou: "The Eph family receptors and ligands." in: Pharmacology & therapeutics, Vol. 77, Issue 3, pp. 151-81, 1998 (PubMed).

Hock, Böhme, Karn et al.: "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 17, pp. 9779-84, 1998 (PubMed).

Trivier, Ganesan: "RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6." in: The Journal of biological chemistry, Vol. 277, Issue 25, pp. 23037-43, 2002 (PubMed).

Alternatives for antigen "EPH Receptor B3 (EPHB3)", type "Antibodies"
Hosts (38), (25), (1), (1)
Reactivities (64), (27), (19), (17), (17), (17), (17)
Applications (51), (32), (19), (18), (13), (10), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (8), (3), (3), (2), (2), (1), (1), (1)
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