Fibulin 5 (FBLN5) (AA 242-448) antibody

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Antigen
Synonyms zgc:103575, FBLN5, MGC108414, Fibulin-5, DKFZp469K0327, ADCL2, ARCL1A, ARMD3, DANCE, EVEC, FIBL-5, UP50, A55
Epitope
AA 242-448
(13), (7), (5), (4), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(82), (28), (25), (13), (4), (1), (1), (1)
Host
Mouse
(48), (32), (6)
Clonality
Monoclonal
Conjugate
Un-conjugated
(5), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(78), (60), (23), (16), (10), (9), (7), (1), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN659371
423.50 $
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Immunogen Purified recombinant fragment of FBLN5(aa242-448) expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of FBLN5(aa242-448) expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name FBLN5
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 50180 DA
Gene ID 12406
NCBI Accession NP_006320
UniProt Q9UBX5
Research Area Cell Signaling, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000, Immunohistochemistry: = 1:200 - 1000.
Comment

Background: FBLN5: fibulin 5. The protein is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Markova, Zou, Ringpfeil et al.: "Genetic heterogeneity of cutis laxa: a heterozygous tandem duplication within the fibulin-5 (FBLN5) gene." in: American journal of human genetics, Vol. 72, Issue 4, pp. 998-1004, 2003 (PubMed).

Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

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