anti-F2RL3 antibody (Coagulation Factor II (Thrombin) Receptor-Like 3) (AA 1-330)

Details for Product anti-F2RL3 Antibody No. ABIN659384
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AA 1-330
(12), (12), (9), (7), (7), (6), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
(116), (58), (56), (3), (2), (1), (1), (1), (1)
(103), (12), (1)
This F2RL3 antibody is un-conjugated
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Immunohistochemistry (IHC), Western Blotting (WB)
(68), (45), (30), (26), (19), (10), (6), (4), (3), (2)
Pubmed 4 references available
Quantity 0.1 mg
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Immunogen Purified recombinant fragment of PAR4(aa1-330) expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of PAR4(aa1-330) expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name PAR4 (F2RL3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 36568 DA
Gene ID 12406
NCBI Accession NP_002574
UniProt Q96IZ0
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Transcription Factors, Signaling, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000, Immunohistochemistry: = 1:200 - 1000.

Background: Prostate apoptosis response 4 (Par4) is a 38kD protein originally identified as the product of a gene that is upregulated in prostate tumor cells undergoing apoptosis. It is a leucine zipper and death domain containing protein whose levels increase in neurons undergoing apoptosis as a result of trophic factor withdrawal or exposure to oxidative and metabolic insults. Par4 levels are reported to be increased in their lumbar spinal cord specimens further suggesting a role in neuronal degeneration. The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms tumor. Par4 is a WT1 interacting protein that also functions as a transcriptional repressor.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Weller, Dahl, Lohoff et al.: "No association between polymorphisms in the prostate apoptosis factor-4 gene and cocaine dependence." in: Psychiatric genetics, Vol. 16, Issue 5, pp. 193-6, 2006 (PubMed).

Gurumurthy, Goswami, Vasudevan et al.: "Phosphorylation of Par-4 by protein kinase A is critical for apoptosis." in: Molecular and cellular biology, Vol. 25, Issue 3, pp. 1146-61, 2005 (PubMed).

Kukoc-Zivojnov, Puccetti, Chow et al.: "Prostate apoptosis response gene-4 (par-4) abrogates the survival function of p185(BCR-ABL) in hematopoietic cells." in: Experimental hematology, Vol. 32, Issue 7, pp. 649-56, 2004 (PubMed).

Xie, Guo: "Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane." in: The Journal of biological chemistry, Vol. 279, Issue 27, pp. 28266-75, 2004 (PubMed).

Catalog No. ABIN659384
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