You are viewing an incomplete version of our website. Please click to reload the website as full version.

Tyrosine Kinase, Non-Receptor, 1 (TNK1) (AA 451-560) antibody

Details for Product No. ABIN659389, Supplier: Login to see New
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

AA 451-560
(30), (18), (7), (6), (5), (4), (4), (3), (2), (1), (1), (1), (1)
(95), (48), (19)
(92), (27), (2)
(8), (8), (8), (7), (7), (7), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(100), (69), (38), (13), (11), (2), (2), (1), (1)
Pubmed 3 references available
Supplier Login to see New
Catalog number from supplier Login to see New
Quantity 0.1 mg
Shipping to United States ( )
Immunogen Purified recombinant fragment of TNK1(aa451-560) expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of TNK1(aa451-560) expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TNK1 (TNK1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 72468 DA
Gene ID 12406
NCBI Accession NP_003976
UniProt Q13470
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Chromatin, Signaling, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000.

Background: TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase(NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Azoitei, Brey, Busch et al.: "Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation." in: Oncogene, Vol. 26, Issue 45, pp. 6536-45, 2007 (PubMed).

Hoare, Hoare, Smith et al.: "Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling." in: Oncogene, Vol. 22, Issue 23, pp. 3562-77, 2003 (PubMed).

Hoehn, Stokland, Amin et al.: "Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells." in: Oncogene, Vol. 12, Issue 4, pp. 903-13, 1996 (PubMed).

Catalog No. ABIN659389

Order hotline:

  • +1 877 302 8632
  • +1 888 205 9894 (TF)