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Details for Product No. ABIN659389

Tyrosine Kinase, Non-Receptor, 1 (TNK1) antibody

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Antigen
Synonyms Ack-like, Kos1, Tnk1a, Tnk1b
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), ELISA
Pubmed 3 references available
Catalog no. ABIN659389
Quantity 0.1 mg
Price
330.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Purified recombinant fragment of TNK1(aa451-560) expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of TNK1(aa451-560) expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TNK1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 72468 DA
Gene ID 12406
UniProt NP_003976.2, Q13470
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Chromatin, Signaling, Cell Structure
Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000.
Comment

Background: TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase(NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Hoehn, Stokland, Amin et al.: "Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells." in: Oncogene, Vol. 12, Issue 4, pp. 903-13, 1996 (PubMed).

Hoare, Hoare, Smith et al.: "Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling." in: Oncogene, Vol. 22, Issue 23, pp. 3562-77, 2003 (PubMed).

Azoitei, Brey, Busch et al.: "Thirty-eight-negative kinase 1 (TNK1) facilitates TNFalpha-induced apoptosis by blocking NF-kappaB activation." in: Oncogene, Vol. 26, Issue 45, pp. 6536-45, 2007 (PubMed).

Alternatives for antigen "Tyrosine Kinase, Non-Receptor, 1 (TNK1)", type "Antibodies"
Hosts (49), (13), (1)
Reactivities (48), (44), (27), (12), (12), (12), (12)
Applications (44), (21), (20), (10), (7), (2), (1), (1), (1)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (13), (4), (3), (2), (2), (1), (1), (1), (1), (1)
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