GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA) antibody

Antigen: GA Binding Protein Transcription Factor, alpha Subunit 60kDa (GABPA)

Synonyms: NFT2, NRF2, NRF2A, E4TF1A, E4TF1-60, Nrf2a, Nrf-2alpha, gabpa-A, XrpFI, X-alpha1, GABPA, gabpa, MGC84637, MGC142634, nft2, nrf2, nrf2a, e4tf1a, e4tf1-60

Clonality: Monoclonal

Host: Mouse

Reactivity: Human

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN659395

Additional Information

Alternative name: GABPA

Gene ID: 2551

UniProt: NP_002031.2, Q06546

Immunogen: Purified recombinant fragment of human GABPA (aa120-190) expressed in E. Coli.

Isotype: IgG1

Description: Other names: NFT2, NRF2

Characteristics: Mouse Monoclonal Antiobody to GABPA

Specificity: Purified recombinant fragment of human GABPA (aa120-190) expressed in E. Coli.

Molecular Weight: 51295 DA

Comments:

Background: GABPA: GA binding protein transcription factor, alpha subunit 60kDa. It is one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, it may play a role in the Down Syndrome phenotype.

Application Details

Application Notes: The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunofluorescence: ~~ 1:200 - 1000.

Buffer: Purified recombinant fragment of human GABPA (aa120-190) expressed in E. Coli.

Storage: GABPA Antibody can be stored at 4?, for long term storage, store at -20?.

Research Area: Transcription Factors, Cell Structure

Restrictions: For Research Use only

Publications

Product: Batchelor, Piper, de la Brousse et al.: "The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA." in: Science (New York, N.Y.), Vol. 279, Issue 5353, pp. 1037-41, 1998 (PubMed).

Sawada, Simizu, Suzuki et al.: "Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family." in: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35475-82, 2000 (PubMed).

Vogel, Kristie: "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP." in: The EMBO journal, Vol. 19, Issue 4, pp. 683-90, 2000 (PubMed).