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Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) antibody
|Synonyms||HGK, NIK, FLH21957, FLJ10410, FLJ20373, FLJ90111, KIAA0687|
Alternatives Western Blotting (WB), ELISA
|3 references available|
|Price||357.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||Purified recombinant fragment of MAP4K4(aa400-500) expressed in E. Coli.|
|Description||Other names: HGK, NIK|
|Characteristics||Mouse Monoclonal Antiobody to MAP4K4|
|Specificity||Purified recombinant fragment of MAP4K4(aa400-500) expressed in E. Coli.|
|Molecular Weight||142101 DA|
Background: MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
|Application Notes||The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000.|
|Buffer||Purified recombinant fragment of MAP4K4(aa400-500) expressed in E. Coli.|
|Storage||MAP4K4 Antibody can be stored at 4?, for long term storage, store at -20?.|
|Research Area||Phospho-specific antibodies, Signaling, Chromatin, Cell Structure|
|Restrictions||For Research Use only|
Becker, Huynh-Do, Holland et al.: "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1537-45, 2000 (PubMed).
Poinat, De Arcangelis, Sookhareea et al.: "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans." in: Current biology : CB, Vol. 12, Issue 8, pp. 622-31, 2002 (PubMed).
Bouzakri, Zierath: "MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance." in: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 7783-9, 2007 (PubMed).