Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) antibody

Details for Product No. ABIN659398
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Antigen
Synonyms FLH21957, HGK, MEKKK4, NIK, 9430080K19Rik, AU043147, AU045934, AW046177, Nik
Reactivity
Human
(121), (65), (52), (49), (48), (13), (13), (1), (1)
Host
Mouse
(97), (26)
Clonality
Monoclonal
Conjugate
Un-conjugated
(4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB)
(69), (48), (40), (25), (13), (9), (7), (5), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN659398
Quantity 0.1 mg
Price
357.50 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of MAP4K4(aa400-500) expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of MAP4K4(aa400-500) expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MAP4K4
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 142101 DA
Gene ID 12406
UniProt O95819, NP_663720.1
Research Area Phospho-specific antibodies, Signaling, Chromatin, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000.
Comment

Background: MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Becker, Huynh-Do, Holland et al.: "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1537-45, 2000 (PubMed).

Poinat, De Arcangelis, Sookhareea et al.: "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans." in: Current biology : CB, Vol. 12, Issue 8, pp. 622-31, 2002 (PubMed).

Bouzakri, Zierath: "MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance." in: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 7783-9, 2007 (PubMed).

Hosts (97), (26)
Reactivities (121), (65), (52), (49), (48), (13), (13), (1), (1)
Applications (69), (48), (40), (25), (13), (9), (7), (5), (1), (1), (1)
Conjugates (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Epitopes (16), (15), (12), (7), (6), (5), (3), (2), (2), (1), (1), (1), (1), (1), (1)
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