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Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) antibody

Antigen

Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4)
Synonyms HGK, NIK, FLH21957, FLJ10410, FLJ20373, FLJ90111, KIAA0687
Clonality Monoclonal
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN659398
Quantity 0.1ml  (Variants)
Price 357.50 $   Plus shipping costs $45.00
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Additional Information
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Alternative name MAP4K4
Gene ID 9448
UniProt O95819, NP_663720.1
Immunogen Purified recombinant fragment of MAP4K4(aa400-500) expressed in E. Coli.
Isotype IgG1
Description Other names: HGK, NIK
Characteristics Mouse Monoclonal Antiobody to MAP4K4
Specificity Purified recombinant fragment of MAP4K4(aa400-500) expressed in E. Coli.
Molecular Weight 142101 DA
Comments

Background: MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.

Application Details
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Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000.
Buffer Purified recombinant fragment of MAP4K4(aa400-500) expressed in E. Coli.
Storage MAP4K4 Antibody can be stored at 4?, for long term storage, store at -20?.
Research Area Phospho-specific antibodies, Signaling, Chromatin, Cell Structure
Restrictions For Research Use only

Publications
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Product Becker, Huynh-Do, Holland et al.: "Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1537-45, 2000 (PubMed).

Poinat, De Arcangelis, Sookhareea et al.: "A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans." in: Current biology : CB, Vol. 12, Issue 8, pp. 622-31, 2002 (PubMed).

Bouzakri, Zierath: "MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance." in: The Journal of biological chemistry, Vol. 282, Issue 11, pp. 7783-9, 2007 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4)", type "Antibodies"
Hosts Rabbit (101), Mouse (12)
Reactivities Human (110), Mouse (Murine) (78), Chicken (20), Cow (Bovine) (20), Pig (Porcine) (20), Rat (Rattus) (20), Dog (Canine) (19), Horse (Equine) (19), Xenopus laevis (1), Zebrafish (1)
Applications Immunofluorescence (IF) (65), Western Blotting (WB) (40), ELISA (39), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (18), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (12), Immunoelectron Microscopy (IEM) (4), Dot Blot (Dot) (3), Immunoprecipitation (IP) (3), Immunocytochemistry (ICC) (1), Immunohistochemistry (IHC) (1)
Conjugates Alexa Fluor 350 (4), Alexa Fluor 488 (4), Alexa Fluor 555 (4), Alexa Fluor 647 (4), Biotin (4), Cy3 (4), Cy5 (4), Cy5.5 (4), Cy7 (4), FITC (4), Gold (4), HRP (4), PE (4), PE,Cy3 (4), PE,Cy5 (4), PE,Cy5.5 (4), PE,Cy7 (4), Alexa Flour 488 (1)
Epitopes pSer631 (21), pSer801 (21), pSer629 (20), C-Term (5), AA 400-500 (4), AA 931-947 (2), Center (1), Internal Region (1), Internal Region,AA 505-534 (1), N-Term (1), pSer63 (1)