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Details for Product No. ABIN659402

Lysyl-tRNA Synthetase (KARS) antibody

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CMTRIB, DFNB89, KARS1, KARS2, KRS, LysRS, AA589550, AL024334, AL033315, AL033367, D8Wsu108e, mKIAA0070, D8Ertd698e, CG12141, Dmel\\CG12141, cb530, wu:fa16h02, zgc:92483, kars, MGC53345, kars2, krs, kr ... show more
»Alternatives Human
»Alternatives Mouse
Clonality Monoclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
Pubmed 4 references available
Catalog no. ABIN659402
Quantity 0.1 mg
357.50 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of KARS(aa90-174) expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of KARS(aa90-174) expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name KARS
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 68048 DA
Gene ID 12406
UniProt NP_005539.1, Q15046
Research Area Translation Factors, Phospho-specific antibodies, Cell Signaling, Cell Structure, Chromatin, Signaling
Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000.

Background: KARS: lysyl-tRNA synthetase. Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Tolkunova, Park, Xia et al.: "The human lysyl-tRNA synthetase gene encodes both the cytoplasmic and mitochondrial enzymes by means of an unusual alternative splicing of the primary transcript." in: The Journal of biological chemistry, Vol. 275, Issue 45, pp. 35063-9, 2000 (PubMed).

Cen, Khorchid, Javanbakht et al.: "Incorporation of lysyl-tRNA synthetase into human immunodeficiency virus type 1." in: Journal of virology, Vol. 75, Issue 11, pp. 5043-8, 2001 (PubMed).

Sang Lee, Gyu Park, Park et al.: "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex." in: Biochemical and biophysical research communications, Vol. 291, Issue 1, pp. 158-64, 2002 (PubMed).

Sampath, Mazumder, Seshadri et al.: "Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation." in: Cell, Vol. 119, Issue 2, pp. 195-208, 2004 (PubMed).

Alternatives for antigen "Lysyl-tRNA Synthetase (KARS)", type "Antibodies"
Hosts (30), (7)
Reactivities (34), (19), (15), (13), (12), (12), (12)
Applications (28), (14), (10), (8), (8), (4), (3), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (3), (3), (2), (2), (1)