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C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (AA 577-650) antibody

Details for Product No. ABIN659406
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Antigen
Synonyms ABL1, ABL, CABL, ABLL, cb272, JTK7, bcr/abl, c-ABL, p150, v-abl, AI325092, Abl, E430008G22Rik, c-Abl, MTP
Epitope
AA 577-650
(49), (35), (31), (26), (25), (17), (16), (14), (13), (13), (13), (12), (12), (12), (12), (12), (12), (12), (12), (11), (9), (7), (7), (6), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(507), (342), (289), (204), (193), (180), (60), (48), (4), (1), (1)
Host
Mouse
(502), (19)
Clonality
Monoclonal
Conjugate
Un-conjugated
(26), (23), (23), (19), (19), (19), (19), (19), (19), (19), (19), (8), (8), (8)
Application
Western Blotting (WB)
(291), (190), (153), (119), (114), (49), (23), (20), (15), (10), (2)
Pubmed 2 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN659406
357.50 $
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Immunogen Purified recombinant fragment of ABL1(aa577-650) expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of ABL1(aa577-650) expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ABL1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 122873 DA
Gene ID 12406
UniProt P00519, NP_009297.2
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Signaling, Chromatin
Application Notes Western Bloting: = 1:500 - 2000.
Comment

Background: ABL1: c-abl oncogene 1, receptor tyrosine kinase. The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Lu, Finnis, Xiang et al.: "Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells." in: Biochemical and biophysical research communications, Vol. 352, Issue 2, pp. 431-6, 2006 (PubMed).

Validation Images
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