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C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) antibody

Antigen

C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)
Synonyms ABL, JTK7, p150, c-ABL, v-abl, bcr/abl, Abl, c-Abl, AI325092, MGC117749, E430008G22Rik, ABL1, ARG, ABLL, FLJ22224, FLJ31718, FLJ41441, Arg, Abll, AA536808, MGC169395, ABL2, CABL, cb272
Clonality Monoclonal
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN659406
Quantity 0.1ml
Price 357.50 $   Plus shipping costs $45.00
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Additional Information
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Alternative name ABL1
Gene ID 25
UniProt P00519, NP_009297.2
Immunogen Purified recombinant fragment of ABL1(aa577-650) expressed in E. Coli.
Isotype IgG1
Description Other names: ABL, JTK7, p150, c-ABL, v-abl
Characteristics Mouse Monoclonal Antiobody to ABL1
Specificity Purified recombinant fragment of ABL1(aa577-650) expressed in E. Coli.
Molecular Weight 122873 DA
Comments

Background: ABL1: c-abl oncogene 1, receptor tyrosine kinase. The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

Application Details
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Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000.
Buffer Purified recombinant fragment of ABL1(aa577-650) expressed in E. Coli.
Storage ABL1 Antibody can be stored at 4?, for long term storage, store at -20?.
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Signaling, Chromatin
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Lu, Finnis, Xiang et al.: "Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells." in: Biochemical and biophysical research communications, Vol. 352, Issue 2, pp. 431-6, 2006 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)", type "Antibodies"
Hosts Rabbit (200), Mouse (16)
Reactivities Human (213), Mouse (Murine) (130), Rat (Rattus) (117), Cow (Bovine) (64), Dog (Canine) (58), Horse (Equine) (58), Pig (Porcine) (58), Guinea Pig (23), Chicken (18), Monkey (2)
Applications Western Blotting (WB) (108), ELISA (90), Immunofluorescence (IF) (90), Immunohistochemistry (IHC) (49), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (43), Immunoprecipitation (IP) (17), Dot Blot (Dot) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (6), Immunocytochemistry (ICC) (5), Immunoelectron Microscopy (IEM) (2), Dot Blot (DB) (1), Flow Cytometry (FACS) (1), Immunodiffusion (ID) (1)
Conjugates Alexa Fluor 350 (11), Alexa Fluor 488 (11), Alexa Fluor 555 (11), Alexa Fluor 647 (11), PE,Cy5.5 (10), Biotin (6), FITC (3), HRP (3), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), Gold (2), PE (2), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1), PE-Cy3 (1), PE-Cy5 (1), PE-Cy5.5 (1), PE-Cy7 (1)
Epitopes pTyr412 (16), Tyr70 (12), pTyr204 (12), pTyr245 (11), C-Term (8), pThr754 (7), pTyr251 (7), pTyr272 (7), pTyr276 (6), pTyr283 (6), pTyr70 (6), pTyr89 (5), N-Term (4), SH2 Domain (3), pThr735,Internal Region (3), AA 577-650 (2), Center (2), Internal Region (2), pThr735 (2), pTyr134 (2), AA 929-1020 (1), N-Term,His246 (1), N-Term,Lys219 (1), Thr735 (1), Tyr251 (1), pSer112 (1), pSer83 (1), pThr309,pThr308 (1), pThr845 (1), pTyr223 (1), pTyr393 (1)