|+1 404 474 4654|
|+1 888 205 9894 (TF)|
C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) antibody
|Synonyms||ABL, JTK7, p150, c-ABL, v-abl, bcr/abl, Abl, c-Abl, AI325092, MGC117749, E430008G22Rik, ABL1, ARG, ABLL, FLJ22224, FLJ31718, FLJ41441, Arg, Abll, AA536808, MGC169395, ABL2, CABL, cb272|
Alternatives Western Blotting (WB), ELISA
|2 references available|
|Price||357.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||Purified recombinant fragment of ABL1(aa577-650) expressed in E. Coli.|
|Description||Other names: ABL, JTK7, p150, c-ABL, v-abl|
|Characteristics||Mouse Monoclonal Antiobody to ABL1|
|Specificity||Purified recombinant fragment of ABL1(aa577-650) expressed in E. Coli.|
|Molecular Weight||122873 DA|
Background: ABL1: c-abl oncogene 1, receptor tyrosine kinase. The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.
|Application Notes||The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000.|
|Buffer||Purified recombinant fragment of ABL1(aa577-650) expressed in E. Coli.|
|Storage||ABL1 Antibody can be stored at 4?, for long term storage, store at -20?.|
|Research Area||Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Signaling, Chromatin|
|Restrictions||For Research Use only|
Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).
Lu, Finnis, Xiang et al.: "Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells." in: Biochemical and biophysical research communications, Vol. 352, Issue 2, pp. 431-6, 2006 (PubMed).