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EPH Receptor A3 antibody (EPHA3) (AA 751-983)

Details for Product anti-EPHA3 Antibody No. ABIN659411, Supplier: Login to see New
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Antigen
Alternatives
Epitope
AA 751-983
(28), (25), (13), (6), (6), (5), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(109), (42), (35), (5), (5), (5), (2), (2), (2), (1), (1), (1), (1)
Host
Mouse
(94), (15), (2), (2)
Clonality
Monoclonal
Conjugate
This EPH Receptor A3 antibody is un-conjugated
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(89), (63), (43), (15), (11), (2), (2), (1), (1), (1)
Pubmed 2 references available
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Quantity 0.1 mg
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Immunogen Purified recombinant fragment of EphA3(aa751-983) expressed in E. Coli.
Isotype IgG2b
Specificity Purified recombinant fragment of EphA3(aa751-983) expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name EphA3 (EPHA3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 109860 DA
Gene ID 12406
NCBI Accession NP_004429
UniProt P54764
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Chromatin, Signaling, Cell Structure
Pathways RTK Signaling
Application Notes Western Bloting: = 1:500 - 2000.
Comment

Background: EphA3: EPH receptor A3. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Janes, Saha, Barton et al.: "Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans." in: Cell, Vol. 123, Issue 2, pp. 291-304, 2005 (PubMed).

Ota, Suzuki, Nishikawa et al.: "Complete sequencing and characterization of 21,243 full-length human cDNAs. ..." in: Nature genetics, Vol. 36, Issue 1, pp. 40-5, 2003 (PubMed).

Catalog No. ABIN659411

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