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Details for Product No. ABIN659423

Nuclear Receptor Co-Repressor 1 (NCOR1) antibody

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Antigen
Synonyms N-CoR, N-CoR1, TRAC1, hN-CoR, Rxrip13, 5730405M06Rik, A230020K14Rik, RIP13, mKIAA1047, ncor, zgc:56355
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
Pubmed 2 references available
Catalog no. ABIN659423
Quantity 0.1 mg
Price
423.50 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of NCOR1(aa1-192) expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of NCOR1(aa1-192) expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name NCOR1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 270210 DA
Gene ID 12406
UniProt NP_006302.2, O75376
Research Area Ubiquitin-related antibodies, Translation Factors, Phospho-specific antibodies, Transcription Factors, Signaling, Chromatin, Cell Structure
Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunohistochemistry: ~~ 1:200 - 1000.
Comment

Background: NCOR1: Nuclear receptor co-repressor 1. This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Zhang, Yoon, Wong: "JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2)." in: Molecular and cellular biology, Vol. 25, Issue 15, pp. 6404-14, 2005 (PubMed).

Atsumi, Tomita, Kiyoi et al.: "Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo." in: Biochemical and biophysical research communications, Vol. 345, Issue 4, pp. 1471-80, 2006 (PubMed).

Alternatives for antigen "Nuclear Receptor Co-Repressor 1 (NCOR1)", type "Antibodies"
Hosts (39), (11), (1)
Reactivities (50), (30), (15), (1)
Applications (41), (24), (21), (13), (10), (5), (4), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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