SRY (Sex Determining Region Y)-Box 2 (SOX2) (AA 1-170) antibody

Details for Product No. ABIN659425
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Antigen
Synonyms Qscn6, Qsox, Sox-2, rSOx, ANOP3, MCOPS3, RGD1565646, SRY-box2, Xsox-2, anop3, mcops3, sox-2, lcc, ysb, cb236, wu:fb83g04, wu:fc14d07, zgc:65860, zgc:77389
Epitope
AA 1-170
(42), (9), (9), (8), (7), (6), (6), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(202), (64), (43), (20), (20), (20), (16), (12), (5), (4), (4), (3), (3), (2), (1), (1), (1)
Host
Mouse
(166), (44), (4)
Clonality
Monoclonal
Conjugate
Un-conjugated
(11), (6), (6), (6), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(150), (71), (42), (33), (31), (30), (26), (26), (11), (10), (10), (9), (5), (3), (1)
Pubmed 2 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN659425
330.00 $
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Immunogen Purified recombinant fragment of SOX2(aa1-170) expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of SOX2(aa1-170) expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SOX2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 34310 DA
Gene ID 12406
NCBI Accession NP_003097
UniProt P48431
Research Area Ubiquitin-related antibodies, Translation Factors, Transcription Factors, Signaling, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000.
Comment

Background: SOX2: SRY (sex determining region Y)-box 2. Entrez Protein NP_003097. It is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Baer, Eriksson, Faull et al.: "Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone." in: Experimental neurology, Vol. 204, Issue 2, pp. 828-31, 2007 (PubMed).

Park, Zhao, West et al.: "Reprogramming of human somatic cells to pluripotency with defined factors." in: Nature, Vol. 451, Issue 7175, pp. 141-6, 2008 (PubMed).

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