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SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody

Antigen

SRY (Sex Determining Region Y)-Box 2 (SOX2)
Synonyms ANOP3, MCOPS3, MGC2413, RGD1565646, SOX2, MGC148683, lcc, ysb, Sox-2
Clonality Monoclonal
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN659425
Quantity 0.1ml  (Variants)
Price 330.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name SOX2
Gene ID 6657
UniProt P48431, NP_003097.1
Immunogen Purified recombinant fragment of SOX2(aa1-170) expressed in E. Coli.
Isotype IgG1
Description Other names: ANOP3, MCOPS3, MGC2413
Characteristics Mouse Monoclonal Antiobody to SOX2
Specificity Purified recombinant fragment of SOX2(aa1-170) expressed in E. Coli.
Molecular Weight 34310 DA
Comments

Background: SOX2: SRY (sex determining region Y)-box 2. Entrez Protein NP_003097. It is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

Application Details
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Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000.
Buffer Purified recombinant fragment of SOX2(aa1-170) expressed in E. Coli.
Storage SOX2 Antibody can be stored at 4?, for long term storage, store at -20?.
Research Area Ubiquitin-related antibodies, Translation Factors, Transcription Factors, Signaling, Cell Structure
Restrictions For Research Use only

Publications
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Product Baer, Eriksson, Faull et al.: "Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone." in: Experimental neurology, Vol. 204, Issue 2, pp. 828-31, 2007 (PubMed).

Park, Zhao, West et al.: "Reprogramming of human somatic cells to pluripotency with defined factors." in: Nature, Vol. 451, Issue 7175, pp. 141-6, 2008 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "SRY (Sex Determining Region Y)-Box 2 (SOX2)", type "Antibodies"
Hosts Rabbit (87), Mouse (18), Goat (4)
Reactivities Human (103), Mouse (Murine) (35), Rat (Rattus) (30), Dog (Canine) (23), Cow (Bovine) (22), Pig (Porcine) (22), Chicken (21), Sheep (Ovine) (20), Guinea Pig (18), Zebrafish (2), Chimpanzee (1), Xenopus laevis (1)
Applications Western Blotting (WB) (74), ELISA (56), Immunofluorescence (IF) (31), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (21), Immunohistochemistry (IHC) (14), Dot Blot (Dot) (6), Flow Cytometry (FACS) (6), Immunocytochemistry (ICC) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoprecipitation (IP) (3), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes N-Term (16), C-Term (4), AA 1-170 (2), AA 50-100 (2), Ala30 (2), Center (2), Cys265 (2), Internal Region (2), AA 100-150 (1), AA 76-80 (1), C-Term, AA 240-260 (1), pSer246 (1), pSer249 (1), pSer250 (1), pSer251 (1), pSer83 (1), pTyr108 (1)