Apolipoprotein O (APOO) antibody

Details for Product No. ABIN659469
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Antigen
Synonyms MGC79016, my025, fam121b, fp74f12, wu:fp74f12, zgc:123314, 0610008C08Rik, 1110019O03Rik, FAM121B, RGD1565289
Reactivity
Human
(34), (19), (13), (13), (12), (12), (12)
Host
Mouse
(27), (7)
Clonality
Monoclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(25), (12), (12), (10), (6)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN659469
357.50 $
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Immunogen Purified recombinant fragment of ApoO expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of ApoO expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ApoO
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 22285 DA
Gene ID 12406
NCBI Accession NP_077027
UniProt Q9BUR5
Research Area Cell Signaling, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000.
Comment

Background: ApoO: apolipoprotein O, also known as MYO25, FAM121B, MGC4825. Entrez Protein NP_077027. It is a chrondroitin-sulfate chain containing member of the apolipoprotein family and is an original glycoprotein up-regulated by diabetes in human Heart. Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Clark, Gurney, Abaya et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, 2003 (PubMed).

Lamant, Smih, Harmancey et al.: "ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart." in: The Journal of biological chemistry, Vol. 281, Issue 47, pp. 36289-302, 2006 (PubMed).

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