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Details for Product No. ABIN659472

Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2) antibody

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Antigen
Synonyms Mlc2, MLC-2, 2410014J02Rik, MLC-2v, Mlc2v, Mylpc, CMH10, MLC2, myosin, regulatory, Mlc-2
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality Monoclonal
Application
»Alternatives Western Blotting (WB), ELISA
Pubmed 2 references available
Catalog no. ABIN659472
Quantity 0.1 mg
Price
330.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Purified recombinant fragment of MYL2 expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of MYL2 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name MYL2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 18789 DA
Gene ID 12406
UniProt P10916, NP_000423.2
Research Area Signaling, Cell Structure
Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000.
Comment

Background: MYL2(myosin, light chain 2, regulatory, cardiac, slow), also known as MLC-2, MLC2v. Entrez protein NP_000423. MYL2 associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. It is an hexamer of two heavy chains and four light chains that is predominantly expressed in adult cardiac ventricle muscle. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Ueda, Murata-Hori, Tatsuka et al.: "Rho-kinase contributes to diphosphorylation of myosin II regulatory light chain in nonmuscle cells." in: Oncogene, Vol. 21, Issue 38, pp. 5852-60, 2002 (PubMed).

Sachdev, Raychowdhury, Sarkar: "Human fast skeletal myosin light chain 2 cDNA: isolation, tissue specific expression of the single copy gene, comparative sequence analysis of isoforms and evolutionary relationships." in: DNA sequence : the journal of DNA sequencing and mapping, Vol. 14, Issue 5, pp. 339-50, 2004 (PubMed).

Alternatives for antigen "Myosin, Light Chain 2, Regulatory, Cardiac, Slow (MYL2)", type "Antibodies"
Hosts (23), (16)
Reactivities (40), (13), (10), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Applications (35), (25), (10), (5), (3), (3), (3), (2), (1)
Epitopes (8), (4), (2), (2)
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