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Details for Product No. ABIN659503

P21-Activated Kinase 2 (PAK2) antibody

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Antigen
Synonyms PAK65, PAKgamma, gamma-PAK, 5330420P17Rik, A130002K10Rik, AI836325, D16Ertd269e, PAK-2, mKIAA4182, pak2, cb422, kinase, zgc:91798, wu:fb71h01, si:dz198m22.1, pak65, pakgamma
Reactivity
»Alternatives Human, Primate
Host
»Alternatives Mouse
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), ELISA
Pubmed 2 references available
Catalog no. ABIN659503
Quantity 0.1 mg
Price
423.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen Purified recombinant fragment of PAK2 expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of PAK2 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name PAK2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 58043 DA
Gene ID 12406
UniProt NP_002568.2, Q13177
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Cell Cycle, Signaling, Chromatin
Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunohistochemistry: ~~ 1:200 - 1000. Immunofluorescence: ~~ 1:200 - 1000.
Comment

Background: PAK2, also known as P21 (CDKN1A)-activated kinase 2. The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. PAK2 is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. PAK2 has been shown to interact with SH3KBP1, CDC42 and Abl gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Chu, Wu, Liao et al.: "A novel role for p21-activated protein kinase 2 in T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 12, pp. 7324-34, 2004 (PubMed).

Machuy, Campa, Thieck et al.: "c-Abl-binding protein interacts with p21-activated kinase 2 (PAK-2) to regulate PDGF-induced membrane ruffles." in: Journal of molecular biology, Vol. 370, Issue 4, pp. 620-32, 2007 (PubMed).

Alternatives for antigen "P21-Activated Kinase 2 (PAK2)", type "Antibodies"
Hosts (150), (11)
Reactivities (156), (113), (112), (37), (36), (12), (5), (1)
Applications (125), (82), (45), (32), (30), (8), (6), (5), (2), (2), (2), (1)
Conjugates (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Epitopes (23), (19), (17), (17), (10), (5), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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