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P21-Activated Kinase 2 (PAK2) antibody

Antigen

P21-Activated Kinase 2 (PAK2)
Synonyms PAK65, PAKgamma, gamma-PAK, PAK-2, AI836325, KIAA4182, mKIAA4182, D16Ertd269e, A130002K10Rik, pak2, cb422, kinase, zgc:91798, wu:fb71h01, si:dz198m22.1, PAK2
Clonality Monoclonal
Host
Alternatives

Mouse
Reactivity
Alternatives

Human, Primate
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), ELISA
2 references available
Certificates ISO 9001:2008
Catalog no. ABIN659503
Quantity 0.1ml
Price 423.50 $   Plus shipping costs $45.00
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Additional Information
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Alternative name PAK2
Gene ID 5062
UniProt NP_002568.2, Q13177
Immunogen Purified recombinant fragment of PAK2 expressed in E. Coli.
Isotype IgG1
Description Other names: PAK65, PAKgamma
Characteristics Mouse Monoclonal Antibody to PAK2
Specificity Purified recombinant fragment of PAK2 expressed in E. Coli.
Molecular Weight 58043 DA
Comments

Background: PAK2, also known as P21 (CDKN1A)-activated kinase 2. The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. PAK2 is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. PAK2 has been shown to interact with SH3KBP1, CDC42 and Abl gene.

Application Details
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Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunohistochemistry: ~~ 1:200 - 1000. Immunofluorescence: ~~ 1:200 - 1000.
Buffer Purified recombinant fragment of PAK2 expressed in E. Coli.
Storage PAK2 Antibody can be stored at 4?, for long term storage, store at -20?.
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Cell Cycle, Signaling, Chromatin
Restrictions For Research Use only

Publications
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Product Chu, Wu, Liao et al.: "A novel role for p21-activated protein kinase 2 in T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 12, pp. 7324-34, 2004 (PubMed).

Machuy, Campa, Thieck et al.: "c-Abl-binding protein interacts with p21-activated kinase 2 (PAK-2) to regulate PDGF-induced membrane ruffles." in: Journal of molecular biology, Vol. 370, Issue 4, pp. 620-32, 2007 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "P21-Activated Kinase 2 (PAK2)", type "Antibodies"
Hosts Rabbit (82), Mouse (4)
Reactivities Human (81), Rat (Rattus) (45), Mouse (Murine) (44), Monkey (2), Cat (Feline) (1), Chicken (1), Cow (Bovine) (1), Dog (Canine) (1), Rabbit (1)
Applications Western Blotting (WB) (59), ELISA (32), Immunofluorescence (IF) (31), Immunohistochemistry (IHC) (16), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (16), Immunoprecipitation (IP) (5), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunocytochemistry (ICC) (2), Flow Cytometry (FACS) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), PE,Cy5.5 (3), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes N-Term (18), C-Term (10), pSer20 (7), pSer141 (5), AA 125-175 (1), AA 25-75 (1), Internal Region (1), pSer144 (1), pSer197 (1), pThr402,pThr423 (1)