Did you know that you can buy products from over 140 different suppliers from us?

GATA Binding Protein 4 (GATA4) antibody

Details for Product No. ABIN659508
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms gata-4, xgata4, xGATA-4, MGC81427, GATA4, GATA-4, Gata4, gata4, ASD2, VSD1, Gata-4, gata
Reactivity
Human
(128), (92), (82), (36), (36), (23), (23), (3)
Host
Mouse
(112), (17), (4), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB)
(97), (48), (35), (29), (19), (17), (3), (3), (2), (1)
Pubmed 3 references available
Quantity 0.1 mg
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN659508
423.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Purified recombinant fragment of human GATA4 expressed in E. Coli.
Isotype IgG2b
Specificity Purified recombinant fragment of human GATA4 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GATA4
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 44565 DA
Gene ID 12406
UniProt NP_002043.2, P43694
Research Area Translation Factors, Phospho-specific antibodies, Transcription Factors, Signaling, Cell Structure
Application Notes Western Bloting: = 1:500 - 2000.
Comment

Background: GATA binding protein 4, also known as GATA4, it is a 46 kDa member of the GATA family of zinc-finger transcription factors. Members of this family is involved in the development of cardiac hypertrophy and remodeling, and plays a critical role in regulating basal and agonist or stress induced gene expression in cardiac and smooth muscle cell types. These factors recognize the GATA motif which is present in the promoters of many genes. GATA4 contains a conserved MAPK phosphorylation site at serine 105 within the transcriptional activation domain. Serine 105 of GATA4 is phosphorylated in response to agonist stimulation through MEK 1 ERK1 / 2, and weakly through JNK or p38 MAPKs. GATA4 is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function. Mutations in this gene have been associated with cardiac septal defects.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Durocher, Charron, Warren et al.: "The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors." in: The EMBO journal, Vol. 16, Issue 18, pp. 5687-96, 1997 (PubMed).

Belaguli, Sepulveda, Nigam et al.: "Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators." in: Molecular and cellular biology, Vol. 20, Issue 20, pp. 7550-8, 2000 (PubMed).

Rajagopal, Ma, Obler et al.: "Spectrum of heart disease associated with murine and human GATA4 mutation." in: Journal of molecular and cellular cardiology, Vol. 43, Issue 6, pp. 677-85, 2007 (PubMed).

Validation Images
back to top