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WNT1 antibody (Wingless-Type MMTV Integration Site Family, Member 1)

Details for Product anti-WNT1 Antibody No. ABIN659520, Supplier: Login to see New
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(103), (34), (14), (5), (3), (3), (2), (2), (2), (2), (1), (1)
(91), (16)
This WNT1 antibody is un-conjugated
(5), (1)
Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
(83), (42), (28), (28), (15), (14), (7), (3), (2), (1), (1), (1)
Pubmed 2 references available
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Catalog number from supplier Login to see New
Quantity 0.1 mg
Shipping to United States ( )
Immunogen Purified recombinant fragment of WNT1 expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of WNT1 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name WNT1 (WNT1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 40982 DA
Gene ID 12406
NCBI Accession NP_005421
UniProt P04628
Research Area Cell Signaling, Cell Structure
Pathways WNT Signaling
Application Notes Western Bloting: = 1:500 - 2000. Immunofluorescence: = 1:200 - 1000. Flow cytometry: = 1:200 - 400.

Background: WNT1: wingless-type MMTV integration site family, member 1. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant rolein Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Woll, Morris, Painschab et al.: "Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells." in: Blood, Vol. 111, Issue 1, pp. 122-31, 2007 (PubMed).

Mikami, You, He et al.: "Efficacy of Wnt-1 monoclonal antibody in sarcoma cells." in: BMC cancer, Vol. 5, pp. 53, 2005 (PubMed).

Catalog No. ABIN659520

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