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Details for Product No. ABIN659520

Wingless-Type MMTV Integration Site Family, Member 1 (WNT1) antibody

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Synonyms BMND16, INT1, OI15, Int-1, Wnt-1, sw, swaying, Int1, WNT-1, int-1, sb:eu647, zgc:194464, zgc:194478, WNT1, Xint-1, Xwnt1, int1, wnt-1, wnt1-a
»Alternatives Human
»Alternatives Mouse
Clonality Monoclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), ELISA
Pubmed 2 references available
Catalog no. ABIN659520
Quantity 0.1 mg
357.50 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of WNT1 expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of WNT1 expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name WNT1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 40982 DA
Gene ID 12406
UniProt NP_005421.1, P04628
Research Area Cell Signaling, Cell Structure
Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunofluorescence: ~~ 1:200 - 1000. Flow cytometry: ~~ 1:200 - 400.

Background: WNT1: wingless-type MMTV integration site family, member 1. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant rolein Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Mikami, You, He et al.: "Efficacy of Wnt-1 monoclonal antibody in sarcoma cells." in: BMC cancer, Vol. 5, pp. 53, 2005 (PubMed).

Woll, Morris, Painschab et al.: "Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells." in: Blood, Vol. 111, Issue 1, pp. 122-31, 2007 (PubMed).

Alternatives for antigen "Wingless-Type MMTV Integration Site Family, Member 1 (WNT1)", type "Antibodies"
Hosts (72), (9)
Reactivities (75), (34), (18), (14), (13), (2), (2), (1), (1), (1)
Applications (54), (34), (25), (13), (10), (8), (7), (5), (2), (1), (1), (1), (1)
Conjugates (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (8), (5), (2), (1), (1), (1), (1), (1)