|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) antibody
|Synonyms||Flk1, Ly73, Flk-1, Krd-1, VEGFR2, VEGFR-2, sVEGFR-2, 6130401C07, FLK1, CD309, VEGFR, Vegfr-2, MGC93590, KDR, FLK-1, flk-1, vegfr-2|
Alternatives Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), ELISA
|3 references available|
|Price||357.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.|
|Description||Other names: FLK1, CD309, VEGFR, VEGFR2|
|Characteristics||Mouse Monoclonal Antibody to KDR|
|Specificity||Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.|
|Molecular Weight||151527 DA|
Background: KDR has also been designated as VEFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
|Application Notes||The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunofluorescence: ~~ 1:200 - 1000. Flow cytometry: ~~ 1:200 - 400.|
|Buffer||Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.|
|Storage||KDR Antibody can be stored at 4?, for long term storage, store at -20?.|
|Research Area||Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Signaling, Chromatin|
|Restrictions||For Research Use only|
Takahashi, Yamaguchi, Chida et al.: "A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells." in: The EMBO journal, Vol. 20, Issue 11, pp. 2768-78, 2001 (PubMed).
Selheim, Holmsen, Vassbotn: "Identification of functional VEGF receptors on human platelets." in: FEBS letters, Vol. 512, Issue 1-3, pp. 107-10, 2002 (PubMed).
Lee, Bone, Strege et al.: "VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia." in: Blood, Vol. 104, Issue 3, pp. 788-94, 2004 (PubMed).