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Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) antibody

Antigen

Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)
Synonyms Flk1, Ly73, Flk-1, Krd-1, VEGFR2, VEGFR-2, sVEGFR-2, 6130401C07, FLK1, CD309, VEGFR, Vegfr-2, MGC93590, KDR, FLK-1, flk-1, vegfr-2
Clonality Monoclonal
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), ELISA
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN659532
Quantity 0.1ml
Price 357.50 $   Plus shipping costs $45.00
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Additional Information
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Alternative name KDR
Gene ID 3791
UniProt P35968, NP_002244.1
Immunogen Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.
Isotype IgG1
Description Other names: FLK1, CD309, VEGFR, VEGFR2
Characteristics Mouse Monoclonal Antibody to KDR
Specificity Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.
Molecular Weight 151527 DA
Comments

Background: KDR has also been designated as VEFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.

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Application Notes The suggested dilution is: ELISA: ~~ 1:10000. Western Bloting: ~~ 1:500 - 2000. Immunofluorescence: ~~ 1:200 - 1000. Flow cytometry: ~~ 1:200 - 400.
Buffer Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.
Storage KDR Antibody can be stored at 4?, for long term storage, store at -20?.
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Signaling, Chromatin
Restrictions For Research Use only

Publications
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Product Takahashi, Yamaguchi, Chida et al.: "A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells." in: The EMBO journal, Vol. 20, Issue 11, pp. 2768-78, 2001 (PubMed).

Selheim, Holmsen, Vassbotn: "Identification of functional VEGF receptors on human platelets." in: FEBS letters, Vol. 512, Issue 1-3, pp. 107-10, 2002 (PubMed).

Lee, Bone, Strege et al.: "VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia." in: Blood, Vol. 104, Issue 3, pp. 788-94, 2004 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR)", type "Antibodies"
Hosts Rabbit (159), Mouse (23), Rat (15), Escherichia Coli (E. coli) (2), Goat (2), Chicken (1)
Reactivities Human (154), Mouse (Murine) (109), Rat (Rattus) (79), Dog (Canine) (20), Chicken (19), Cow (Bovine) (19), Pig (Porcine) (18), Cat (Feline) (1)
Applications Western Blotting (WB) (132), Immunohistochemistry (IHC) (83), ELISA (64), Immunofluorescence (IF) (57), Flow Cytometry (FACS) (48), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (27), Immunoprecipitation (IP) (13), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (5), Neutralization (Neut) (5), Immunocytochemistry (ICC) (3), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunohistochemistry (Frozen Sections) (IHC (fro)) (2), Dot Blot (Dot) (1), Immunoelectron Microscopy (IEM) (1)
Conjugates Biotin (10), PE (4), APC (2), Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), FITC (2), PE,Cy5.5 (2), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), E-Tag (1), Gold (1), HRP (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pTyr951 (17), C-Term (16), pTyr1175 (12), pTyr1214 (10), Internal Region (5), Tyr1175 (3), Tyr1214 (3), Tyr951 (3), pTyr1054 (3), pTyr1059 (3), pTyr996 (3), AA 1158-1345 (2), N-Term (2), pY1054 (2), AA 20-762 (1), AA 20-764 (1), Extracellular Domain (1), Extracellular,AA 20-764 (1), pTyr1054, pTyr1059 (1), pY951 (1)