Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) antibody

Details for Product No. ABIN659532
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Antigen
Synonyms FLK1, CD309, VEGFR, VEGFR2, Vegfr-2, FLK-1, flk-1, FLK/KDR, vegfr-2, KDR
Reactivity
Human
(448), (279), (187), (64), (63), (52), (49), (26), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Host
Mouse
(416), (71), (33), (3), (3), (2)
Clonality
Monoclonal
Conjugate
Un-conjugated
(34), (8), (8), (6), (6), (6), (6), (6), (6), (6), (6), (6), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
(352), (158), (148), (126), (76), (73), (60), (46), (31), (24), (8), (7), (4), (3), (2), (1)
Pubmed 3 references available
Catalog no. ABIN659532
Quantity 0.1 mg
Price
357.50 $   Plus shipping costs $45.00
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Immunogen Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.
Isotype IgG1
Specificity Purified recombinant extracellular fragment of human KDR (aa20-764) fused with hIgGFc tag expressed in HEK293 cells.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name KDR
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 151527 DA
Gene ID 12406
UniProt P35968, NP_002244.1
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Signaling, Chromatin
Application Notes Western Bloting: = 1:500 - 2000. Immunofluorescence: = 1:200 - 1000. Flow cytometry: = 1:200 - 400.
Comment

Background: KDR has also been designated as VEFR-2 (Vascular endothelial growth factor receptor 2), CD309 (cluster of differentiation 309) and Flk1 (fetal liver kinase 1). Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. KDR is one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Takahashi, Yamaguchi, Chida et al.: "A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells." in: The EMBO journal, Vol. 20, Issue 11, pp. 2768-78, 2001 (PubMed).

Selheim, Holmsen, Vassbotn: "Identification of functional VEGF receptors on human platelets." in: FEBS letters, Vol. 512, Issue 1-3, pp. 107-10, 2002 (PubMed).

Lee, Bone, Strege et al.: "VEGF receptor phosphorylation status and apoptosis is modulated by a green tea component, epigallocatechin-3-gallate (EGCG), in B-cell chronic lymphocytic leukemia." in: Blood, Vol. 104, Issue 3, pp. 788-94, 2004 (PubMed).

Hosts (416), (71), (33), (3), (3), (2)
Reactivities (448), (279), (187), (64), (63), (52), (49), (26), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Applications (352), (158), (148), (126), (76), (73), (60), (46), (31), (24), (8), (7), (4), (3), (2), (1)
Conjugates (34), (8), (8), (6), (6), (6), (6), (6), (6), (6), (6), (6), (4), (4), (3), (3), (3), (2), (1), (1), (1), (1)
Epitopes (45), (42), (41), (38), (26), (19), (17), (15), (12), (10), (7), (7), (6), (5), (4), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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