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Wingless-Type MMTV Integration Site Family, Member 10B (WNT10B) antibody

Details for Product No. ABIN659533
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Antigen
Synonyms WNT10B, Xwnt-10b, Xwnt10b, wnt-12, Wnt12, SHFM6, WNT-12, Xwnt-10, wnt10, wnt10-A, Zwnt[d], wnt10br, wnt[d]
Reactivity
Human
(45), (24), (21), (13), (13), (13)
Host
Mouse
(40), (7)
Clonality
Monoclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(32), (20), (18), (15), (10), (8), (6), (3), (1)
Pubmed 2 references available
Quantity 0.1 mg
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Catalog No. ABIN659533
423.50 $
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Immunogen Purified recombinant fragment of human WNT10B expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of human WNT10B expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name WNT10B
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 43000 DA
Gene ID 12406
UniProt NP_003385.2, O00744
Research Area Phospho-specific antibodies, Cell Structure
Application Notes The suggested dilution is: Western Bloting: = 1:500 - 2000. Immunohistochemistry: = 1:200 - 1000. Immunofluorescence: = 1:200 - 1000.
Comment

Background: WNT10B: wingless-type MMTV integration site family, member 10B. The WNT family consists of structurally related secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. WNT10B is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is ikely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10B protein at the amino acid level. The WNT10B gene is clustered with another family member, WNT1, in the chromosome 12q13 region.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Bui, Rankin, Smith et al.: "A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas." in: Oncogene, Vol. 14, Issue 10, pp. 1249-53, 1997 (PubMed).

Saitoh, Kirikoshi, Mine et al.: "Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45." in: International journal of oncology, Vol. 19, Issue 6, pp. 1187-92, 2001 (PubMed).

Validation Images
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