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ENOS antibody (Nitric Oxide Synthase 3 (Endothelial Cell))

Details for Product anti-NOS3 Antibody No. ABIN659535, Supplier: Login to see New
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(389), (214), (202), (35), (33), (11), (11), (11), (4), (2), (2), (1), (1), (1)
(426), (40)
This ENOS antibody is un-conjugated
(29), (24), (16), (8), (7), (6), (6), (6), (6), (6), (6), (6), (6), (5), (5)
Immunohistochemistry (IHC)
(291), (171), (71), (70), (68), (60), (32), (23), (21), (19), (12), (11), (5), (2), (2), (1), (1)
Pubmed 3 references available
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Quantity 0.1 mg
Shipping to United States ( )
Immunogen Purified recombinant fragment of human eNOS expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of human eNOS expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name eNOS (NOS3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 133289 DA
Gene ID 12406
NCBI Accession NP_001153582
UniProt P29474
Research Area Phospho-specific antibodies, Metabolism, Cell Structure
Pathways ACE Inhibitor Pathway
Application Notes Immunohistochemistry: = 1:200 - 1000

Background: Endothelial nitric-oxide synthase (eNOS), also known as NOS3, it is an important enzyme in the cardiovascular system. It is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Moreno: "Genetic polymorphisms and haplotypes of eNOS in breast cancer." in: Breast cancer research and treatment, Vol. 109, Issue 1, pp. 181-2, 2008 (PubMed).

Lahiri, Martin: "Reduced expression of endothelial and inducible nitric oxide synthase in a multidrug resistant variant of the MCF-7 human breast cancer cell line." in: Oncology reports, Vol. 12, Issue 5, pp. 1007-11, 2004 (PubMed).

Dimmeler, Fleming, Fisslthaler et al.: "Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation." in: Nature, Vol. 399, Issue 6736, pp. 601-5, 1999 (PubMed).

Catalog No. ABIN659535

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