Nitric Oxide Synthase 3 (Endothelial Cell) (NOS3) antibody

Details for Product No. ABIN659535
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Antigen
Synonyms eNOS, Nos-3, ecNOS, 2310065A03Rik, cNOS, EC-NOS, NOSIII, NOS, ECNOS, eNos, ENOS, NOS3
Reactivity
Human
(288), (195), (195), (82), (69), (65), (37), (4), (2), (1), (1), (1), (1)
Host
Mouse
(305), (23), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(14), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8)
Application
Immunohistochemistry (IHC)
(202), (135), (80), (77), (42), (29), (29), (12), (10), (8), (6), (3), (1), (1), (1), (1)
Pubmed 3 references available
Catalog no. ABIN659535
Quantity 0.1 mg
Price
357.50 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of human eNOS expressed in E. Coli.
Isotype IgG1
Specificity Purified recombinant fragment of human eNOS expressed in E. Coli.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name eNOS
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 133289 DA
Gene ID 12406
UniProt P29474, NP_001153582.1
Research Area Phospho-specific antibodies, Metabolism, Cell Structure
Application Notes Immunohistochemistry: = 1:200 - 1000
Comment

Background: Endothelial nitric-oxide synthase (eNOS), also known as NOS3, it is an important enzyme in the cardiovascular system. It is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Dimmeler, Fleming, Fisslthaler et al.: "Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation." in: Nature, Vol. 399, Issue 6736, pp. 601-5, 1999 (PubMed).

Lahiri, Martin: "Reduced expression of endothelial and inducible nitric oxide synthase in a multidrug resistant variant of the MCF-7 human breast cancer cell line." in: Oncology reports, Vol. 12, Issue 5, pp. 1007-11, 2004 (PubMed).

Moreno: "Genetic polymorphisms and haplotypes of eNOS in breast cancer." in: Breast cancer research and treatment, Vol. 109, Issue 1, pp. 181-2, 2008 (PubMed).

Hosts (305), (23), (1)
Reactivities (288), (195), (195), (82), (69), (65), (37), (4), (2), (1), (1), (1), (1)
Applications (202), (135), (80), (77), (42), (29), (29), (12), (10), (8), (6), (3), (1), (1), (1), (1)
Conjugates (14), (8), (8), (8), (8), (8), (8), (8), (8), (8), (8)
Epitopes (30), (25), (25), (16), (16), (15), (15), (13), (12), (12), (8), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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